Towards Biosensing Strategies Based on Biochemical Logic Systems

Abstract

Recent advances in biochemical computing, i.e., information processing with cascades of primarily enzymatic reactions realizing computing gates, such as AND, OR, etc., as well as progress in networking these gates and coupling of the resulting systems to smart/responsive electrodes for output readout, have opened new biosensing opportunities. Here we survey existing enabling research results, as well as ideas and research avenues for future development of a new paradigm of digitally operating biosensors logically processing multiple biochemical signals through Boolean logic networks composed of biomolecular reactions, yielding the final output signals as YES/NO responses. Such systems can lead to high-fidelity biosensing compared to common single or parallel sensing devices.

References in corpus (5)

• Optimization of Enzymatic Biochemical Logic for Noise Reduction and Scalability: How Many Biocomputing Gates Can Be Interconnected in a Circuit?
• Network Analysis of Biochemical Logic for Noise Reduction and Stability: A System of Three Coupled Enzymatic AND Gates
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Cited by in corpus (5)

• Enzymatic AND Logic Gates Operated Under Conditions Characteristic of Biomedical Applications
• Biochemical Filter with Sigmoidal Response: Increasing the Complexity of Biomolecular Logic
• Kinetic Model for a Threshold Filter in an Enzymatic System for Bioanalytical and Biocomputing Applications
• Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications
• Modeling and Modifying Response of Biochemical Processes for Biocomputing and Biosensing Signal Processing