Enzyme-Based Logic: OR Gate with Double-Sigmoid Filter Response

Abstract

The first realization of a biomolecular OR gate function with double-sigmoid response (sigmoid in both inputs) is reported. Two chemical inputs activate the enzymatic gate processes resulting in the output signal: chromogen oxidation, which occurs when either one of the inputs or both are present (corresponding to the OR binary function), and can be optically detected. High-quality gate functioning in handling of sources of noise is enabled by "filtering" involving pH control with an added buffer. The resulting gate response is sigmoid in both inputs when proper system parameters are chosen, and the gate properties are theoretically analyzed within a model devised to evaluate its noise-handling properties.

References in corpus (4)

• Enzymatic AND Logic Gates Operated Under Conditions Characteristic of Biomedical Applications
• Enzyme-Based Logic Analysis of Biomarkers at Physiological Concentrations: AND Gate with Double-Sigmoid "Filter" Response
• Biochemical Filter with Sigmoidal Response: Increasing the Complexity of Biomolecular Logic
• Control of Noise in Chemical and Biochemical Information Processing

Cited by in corpus (11)

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• Kinetic Model for a Threshold Filter in an Enzymatic System for Bioanalytical and Biocomputing Applications
• Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications
• Notes on stochastic (bio)-logic gates: the role of allosteric cooperativity
• Can bio-inspired information processing steps be realized as synthetic biochemical processes?
• Modeling and Modifying Response of Biochemical Processes for Biocomputing and Biosensing Signal Processing
• Theoretical Modeling Expressions for Networked Enzymatic Signal Processing Steps as Logic Gates Optimized by Filtering
• Towards proteinoid computers
• Two-Input Enzymatic Logic Gates Made Sigmoid by Modifications of the Biocatalytic Reaction Cascades