Enzymatic AND Logic Gate with Sigmoid Response Induced by Photochemically Controlled Oxidation of the Output

Abstract

We report a study of a system which involves an enzymatic cascade realizing an AND logic gate, with an added photochemical processing of the output allowing to make the gate's response sigmoid in both inputs. New functional forms are developed for quantifying the kinetics of such systems, specifically designed to model their response in terms of signal and information processing. These theoretical expressions are tested for the studied system, which also allows us to consider aspects of biochemical information processing such as noise transmission properties and control of timing of the chemical and physical steps.

References in corpus (4)

• Enzymatic AND Logic Gates Operated Under Conditions Characteristic of Biomedical Applications
• Enzyme-Based Logic Analysis of Biomarkers at Physiological Concentrations: AND Gate with Double-Sigmoid "Filter" Response
• Biochemical Filter with Sigmoidal Response: Increasing the Complexity of Biomolecular Logic
• Control of Noise in Chemical and Biochemical Information Processing

Cited by in corpus (7)

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• Can bio-inspired information processing steps be realized as synthetic biochemical processes?
• Modeling and Modifying Response of Biochemical Processes for Biocomputing and Biosensing Signal Processing
• Theoretical Modeling Expressions for Networked Enzymatic Signal Processing Steps as Logic Gates Optimized by Filtering
• Rate-Equation Modelling and Ensemble Approach to Extraction of Parameters for Viral Infection-Induced Cell Apoptosis and Necrosis