Transverse conductance of DNA nucleotides in a graphene nanogap from first principles
arXiv:1012.1669 · doi:10.1021/nl200147x
Abstract
The fabrication of nanopores in atomically-thin graphene has recently been achieved and translocation of DNA has been demonstrated. Taken together with an earlier proposal to use graphene nanogaps for the purpose of DNA sequencing, this approach can resolve the technical problem of achieving single-base resolution in electronic nucleobase detection. We have theoretically evaluated the performance of a graphene nanogap setup for the purpose of whole-genome sequencing, by employing density functional theory and the non-equilibrium Green's function method to investigate the transverse conductance properties of nucleotides inside the gap. In particular, we determined the electrical tunneling current variation at finite bias due to changes in the nucleotides orientation and lateral position. Although the resulting tunneling current is found to fluctuate over several orders of magnitudes, a distinction between the four DNA bases appears possible, thus ranking the approach promising for rapid whole-genome sequencing applications.
arXiv comment12 pages, 3 figures
References in corpus (11)
- Electric Field Effect in Atomically Thin Carbon Films
- The electronic properties of graphene
- Selfconsistent order-N density-functional calculations for very large systems
- Graphene: A sub-nanometer trans-electrode membrane
- DNA Translocation through Graphene Nanopores
- Fast DNA translocation through a solid-state nanopore
- Electron beam nanosculpting of suspended graphene sheets
- Fast DNA Sequencing via Transverse Electronic Transport
- Electronic signature of DNA nucleotides via transverse transport
- Conductivity engineering of graphene by defect formation
- Functionalized nanopore-embedded electrodes for rapid DNA sequencing
Cited by in corpus (22)
- Carbon nanomaterials for electronics, optoelectronics, photovoltaics, and sensing
- DNA nucleotide-specific modulation of μA transverse edge currents through a metallic graphene nanoribbon with a nanopore
- Single-molecule techniques in biophysics: a review of the progress in methods and applications
- Silicene as a new ultrafast DNA sequencing device
- Transverse Electronic Transport through DNA Nucleotides with Functionalized Graphene Electrodes
- Recent progress in atomistic simulation of electrical current DNA sequencing
- Interface of graphene nanopore and hexagonal boron nitride as a sensing device
- First-principles study of high conductance DNA sequencing with carbon nanotube electrodes
- Polymer translocation through nano-pores in vibrating thin membranes
- Correlation Dynamics and Enhanced Signals for Serial DNA Sequencing
- Graphene Nanogap for Gate Tunable Quantum Coherent Single Molecule Electronics
- First-principles vs. semi-empirical modeling of global and local electronic transport properties of graphene nanopore-based sensors for DNA sequencing
- Identification of DNA Bases Using Nanopores Created in Finite-Size Nanoribbons from Graphene, Phosphorene, and Silicene
- ssDNA sequencing by rectification
- Detection of basepair mismatches in DNA using graphene based nanopore device
- Distinct mechanisms of DNA sensing based on N-doped carbon nanotubes with enhanced conductance and chemical selectivity
- DNA-Graphene Interactions During Translocation Through Nanogaps
- Nitrogen doping of carbon nanoelectrodes for enhanced control of DNA translocation dynamics
- Graphene nanopore devices for DNA sequencing: A tight-binding model study
- Mechano-switching devices from carbon wire-carbon nanotube junctions
- Field effect and local gating in nitrogen-terminated nanopores (NtNP) and nanogaps (NtNG) in graphene
- Nanopore-Based DNA Sequencing Sensors and CMOS Readout Approaches