Recent progress in atomistic simulation of electrical current DNA sequencing

Abstract

We review recent advances in the DNA sequencing based on the measurement of transverse electrical currents. Device configurations proposed in the literature are classified according to whether the molecular fingerprints appear as the major (Mode I) or perturbing (Mode II) current signals. Scanning tunneling microscope and tunneling electrode gap configurations belong to the former category, while the nanochannels with or without an embedded nanopore belong to the latter. The molecular sensing mechanisms of Modes I and II roughly correspond to the electron tunneling and electrochemical gating, respectively. Special emphasis will be given on the computer simulation studies, which have been playing a critical role in the initiation and development of the field. We also highlight low-dimensional nanomaterials such as carbon nanotubes, graphene, and graphene nanoribbons that allow the novel Mode II approach. Finally, several issues in previous computational studies are discussed, which points to future research directions toward more reliable simulation of electrical current DNA sequencing devices.

38 pages, 7 figures, 1 table

References in corpus (23)

• Van der Waals heterostructures
• Electronic transport in two dimensional graphene
• Graphene: A sub-nanometer trans-electrode membrane
• DNA Translocation through Graphene Nanopores
• Observation of Quantum Interference in Molecular Charge Transport
• Physical approaches to DNA sequencing and detection
• Fast DNA Sequencing via Transverse Electronic Transport
• Charge Transport in Disordered Graphene-Based Low Dimensional Materials
• Electronic signature of DNA nucleotides via transverse transport
• DNA nucleotide-specific modulation of μA transverse edge currents through a metallic graphene nanoribbon with a nanopore
• Transverse conductance of DNA nucleotides in a graphene nanogap from first principles
• Influence of the environment and probes on rapid DNA sequencing via transverse electronic transport
• Transverse Electronic Transport through DNA Nucleotides with Functionalized Graphene Electrodes
• Enhanced DNA sequencing performance through edge-hydrogenation of graphene electrodes
• Functionalized nanopore-embedded electrodes for rapid DNA sequencing
• Effect of Noise on DNA Sequencing via Transverse Electronic Transport
• Silicene-based DNA Nucleobase Sensing
• Comment on "Characterization of the tunneling conductance across DNA bases"
• First-principles study of high conductance DNA sequencing with carbon nanotube electrodes
• Correlation Dynamics and Enhanced Signals for Serial DNA Sequencing
• First-principles vs. semi-empirical modeling of global and local electronic transport properties of graphene nanopore-based sensors for DNA sequencing
• Distinct mechanisms of DNA sensing based on N-doped carbon nanotubes with enhanced conductance and chemical selectivity
• Bilayer Graphene Lateral Contacts for DNA Sequencing

Cited by in corpus (7)

• Origin and Control of Polyacrylonitrile Alignments on Carbon Nanotube and Graphene Nanoribbon
• ssDNA sequencing by rectification
• Nitrogen doping of carbon nanoelectrodes for enhanced control of DNA translocation dynamics
• Convolutional network learning of self-consistent electron density via grid-projected atomic fingerprints
• Odd-even phonon transport effects in strained carbon atomic chains bridging graphene nanoribbon electrodes
• Electronic Transport through DNA Nucleotides in a BC${}_3$ Nanogap for Rapid DNA Sequencing
• Computational modeling of biological nanopores