Detection of basepair mismatches in DNA using graphene based nanopore device
arXiv:1508.07787 · doi:10.1088/0957-4484/27/13/135101
Abstract
We present an unique way to detect basepair mismatches in DNA leading to different epigenetic disorder by the method of nanopore sequencing. Based on a tight-binding formulation of graphene nanopore based device, using Greens function approach we measure the changes in the electronic transport properties of the device as we translocate a double-stranded DNA through the nanopore embeded in a zigzag graphene nanoribbon. In the present work we not only successfully detect the usual AT and GC pairs, but also a set of possible mismatches in the complementary base-pairing without any ambiguity. Our investigation shows that this device can also be used for reliable sequential detection of other biomolecules.
Accepted in Nanotechnology, 12 pages, 7 figures
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