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5 papers · 2 filters
A Bayesian hierarchical model for bridging across patient subgroups in phase I clinical trials with animal data
Haiyan Zheng, Lisa V. Hampson, Thomas Jaki
Incorporating preclinical animal data, which can be regarded as a special kind of historical data, into phase I clinical trials can improve decision making when very little about h…
An efficient and robust approach to Mendelian randomization with measured pleiotropic effects in a high-dimensional setting
Andrew J. Grant, Stephen Burgess
Valid estimation of a causal effect using instrumental variables requires that all of the instruments are independent of the outcome conditional on the risk factor of interest and…
Bayesian design and analysis of external pilot trials for complex interventions
Duncan T. Wilson, James M. S. Wason, Julia Brown +2
External pilot trials of complex interventions are used to help determine if and how a confirmatory trial should be undertaken, providing estimates of parameters such as recruitmen…
Borrowing of information across patient subgroups in a basket trial based on distributional discrepancy
Haiyan Zheng, James M. S. Wason
Basket trials have emerged as a new class of efficient approaches in oncology to evaluate a new treatment in several patient subgroups simultaneously. In this paper, we extend the…
A guide to Value of Information methods for prioritising research in health impact modelling
Rob Johnson, James Woodcock, Audrey de Nazelle +4
Health impact simulation models are used to predict how a proposed intervention or scenario will affect public health outcomes, based on available data and knowledge of the process…