4 papers
Conditional Power and Friends: The Why and How of (Un)planned, Unblinded Sample Size Recalculations in Confirmatory Trials
Kevin Kunzmann, Michael J. Grayling, Kim M. Lee +3
Adapting the final sample size of a trial to the evidence accruing during the trial is a natural way to address planning uncertainty. Designs with adaptive sample size need to acco…
Online control of the false discovery rate in biomedical research
David S. Robertson, James M. S. Wason
Modern biomedical research frequently involves testing multiple related hypotheses, while maintaining control over a suitable error rate. In many applications the false discovery r…
Design optimisation and post-trial analysis in group sequential stepped-wedge cluster randomised trials
Michael Grayling, David Robertson, James Wason +1
Recently, methodology was presented to facilitate the incorporation of interim analyses in stepped-wedge (SW) cluster randomised trials (CRTs). Here, we extend this previous discus…
Familywise error control in multi-armed response-adaptive trials
David S. Robertson, James M. S. Wason
Response-adaptive designs allow the randomization probabilities to change during the course of a trial based on cumulated response data, so that a greater proportion of patients ca…