500 citations
- University of CambridgeGB11 papers
- MRC Laboratory of Molecular BiologyGB9 papers
- Imperial College LondonGB7 papers
- MRC Biostatistics UnitGB6 papers
- University College LondonGB5 papers
- London School of Hygiene & Tropical MedicineGB4 papers
- Centre National de la Recherche ScientifiqueFR3 papers
- Duke-NUS Medical SchoolSG2 papers
- Duke UniversityUS2 papers
- Harvard UniversityUS2 papers
- Massachusetts Institute of TechnologyUS2 papers
- MRC Clinical Trials Unit at UCLGB2 papers
31 papers
Introducing precision-weighted bias as a performance measure to inform the inclusion of adaptive designs in meta-analysis
Martin Law, David S. Robertson, Sofia S. Villar +4
We propose a novel, intuitive measure of statistical performance: precision-weighted bias. Precision-weighted bias is defined as the unconditional bias of an estimator weighted by…
Unlocking Electronic Health Records: A Hybrid Graph RAG Approach to Safe Clinical AI for Patient QA
Samuel Thio, Matthew Lewis, Spiros Denaxas +1
Electronic health record (EHR) systems present clinicians with vast repositories of clinical information, creating a significant cognitive burden where critical details are easily…
Multivariate Adjustments for Average Equivalence Testing
Younes Boulaguiem, Luca Insolia, Maria-Pia Victoria-Feser +2
Multivariate (average) equivalence testing is widely used to assess whether the means of two conditions of interest are `equivalent' for different outcomes simultaneously. The mult…
Mathematical modelling to inform outbreak response vaccination
Manjari Shankar, Anna-Maria Hartner, Callum R. K. Arnold +11
Mathematical models are established tools to assist in outbreak response. They help characterise complex patterns in disease spread, simulate control options to assist public healt…
On the design space between molecular mechanics and machine learning force fields
Yuanqing Wang, Kenichiro Takaba, Michael S. Chen +14
A force field as accurate as quantum mechanics (QM) and as fast as molecular mechanics (MM), with which one can simulate a biomolecular system efficiently enough and meaningfully e…
Efficient high-resolution refinement in cryo-EM with stochastic gradient descent
Bogdan Toader, Marcus A. Brubaker, Roy R. Lederman
Electron cryomicroscopy (cryo-EM) is an imaging technique widely used in structural biology to determine the three-dimensional structure of biological molecules from noisy two-dime…