46 citations · 79 across the 7 of their papers we have counts for
7 papers
A Bayesian Phase I/II basket design with robust information borrowing to identify subtrial-specific optimal biological doses
Zhi Cao, Haiyan Zheng, Pavel Mozgunov
The objective of modern early oncology dose-finding is to identify an optimal biological dose (OBD), rather than simply the maximum tolerated dose. In basket trials, the dose-toxic…
Bayesian sample size determination in basket trials borrowing information between subsets
Haiyan Zheng, Michael J. Grayling, Pavel Mozgunov +2
Basket trials are increasingly used for the simultaneous evaluation of a new treatment in various patient subgroups under one overarching protocol. We propose a Bayesian approach t…
A Bayesian adaptive design for dual-agent phase I-II oncology trials integrating efficacy data across stages
José L. Jiménez, Haiyan Zheng
Combination of several anti-cancer treatments has typically been presumed to have enhanced drug activity. Motivated by a real clinical trial, this paper considers phase I-II dose f…
Bayesian sample size determination using commensurate priors to leverage pre-experimental data
Haiyan Zheng, Thomas Jaki, James M. S. Wason
This paper develops Bayesian sample size formulae for experiments comparing two groups. We assume the experimental data will be analysed in the Bayesian framework, where pre-experi…
A Bayesian hierarchical model for bridging across patient subgroups in phase I clinical trials with animal data
Haiyan Zheng, Lisa V. Hampson, Thomas Jaki
Incorporating preclinical animal data, which can be regarded as a special kind of historical data, into phase I clinical trials can improve decision making when very little about h…
Borrowing of information across patient subgroups in a basket trial based on distributional discrepancy
Haiyan Zheng, James M. S. Wason
Basket trials have emerged as a new class of efficient approaches in oncology to evaluate a new treatment in several patient subgroups simultaneously. In this paper, we extend the…
A Bayesian decision-theoretic approach to incorporate preclinical information into phase I oncology trials
Haiyan Zheng, Lisa V. Hampson
Leveraging preclinical animal data for a phase I first-in-man trial is appealing yet challenging. A prior based on animal data may place large probability mass on values of the dos…