4 papers
A Bayesian Phase I/II basket design with robust information borrowing to identify subtrial-specific optimal biological doses
Zhi Cao, Haiyan Zheng, Pavel Mozgunov
The objective of modern early oncology dose-finding is to identify an optimal biological dose (OBD), rather than simply the maximum tolerated dose. In basket trials, the dose-toxic…
A Bayesian hierarchical model for bridging across patient subgroups in phase I clinical trials with animal data
Haiyan Zheng, Lisa V. Hampson, Thomas Jaki
Incorporating preclinical animal data, which can be regarded as a special kind of historical data, into phase I clinical trials can improve decision making when very little about h…
Borrowing of information across patient subgroups in a basket trial based on distributional discrepancy
Haiyan Zheng, James M. S. Wason
Basket trials have emerged as a new class of efficient approaches in oncology to evaluate a new treatment in several patient subgroups simultaneously. In this paper, we extend the…
A Bayesian decision-theoretic approach to incorporate preclinical information into phase I oncology trials
Haiyan Zheng, Lisa V. Hampson
Leveraging preclinical animal data for a phase I first-in-man trial is appealing yet challenging. A prior based on animal data may place large probability mass on values of the dos…