3 papers
stat.AP2025
Robust Bayesian hierarchical models for basket trials enabling joint evaluation of toxicity and efficacy
Zhi Cao, Pavel Mozgunov, Haiyan Zheng
Basket trials have gained increasing attention for their efficiency, as multiple patient subgroups are evaluated simultaneously. Conducted basket trials focus primarily on establis…
stat.ME2025
A Bayesian Treatment Selection Design for Phase II Randomised Cancer Clinical Trials
Moka Komaki, Satoru Shinoda, Haiyan Zheng +1
It is crucial to design Phase II cancer clinical trials that balance the efficiency of treatment selection with clinical practicality. Sargent and Goldberg proposed a frequentist d…
stat.ME2024
Next generation clinical trials: Seamless designs and master protocols
Abigail Burdon, Thomas Jaki, Xijin Chen +3
Background: Drug development is often inefficient, costly and lengthy, yet it is essential for evaluating the safety and efficacy of new interventions. Compared with other disease…