500 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- University of CambridgeGB71 papers
- University College LondonGB12 papers
- Newcastle UniversityGB11 papers
- Imperial College LondonGB8 papers
- The Alan Turing InstituteGB7 papers
- Medical Research CouncilGB6 papers
- Sapienza University of RomeIT6 papers
- Novartis (Switzerland)CH5 papers
- Public Health EnglandGB5 papers
- UK Health Security AgencyGB5 papers
- University of OxfordGB5 papers
- Amsterdam University Medical CentersNL4 papers
21 papers · 1 filter
Implementing Response-Adaptive Randomisation in Stratified Rare-disease Trials: Design Challenges and Practical Solutions
Rajenki Das, Nina Deliu, Mark Toshner +1
Although response-adaptive randomisation (RAR) has gained substantial attention in the literature, it still has limited use in clinical trials. Amongst other reasons, the implement…
Normative brain mapping of 3-dimensional morphometry imaging data using skewed functional data analysis
Marco Palma, Shahin Tavakoli, Julia Brettschneider +2
Tensor-based morphometry (TBM) aims at showing local differences in brain volumes with respect to a common template. TBM images are smooth but they exhibit (especially in diseased…
The NOSTRA model: coherent estimation of infection sources in the case of possible nosocomial transmission
David J Pascall, Chris Jackson, Stephanie Evans +8
Nosocomial infections have important consequences for patients and hospital staff: they worsen patient outcomes and their management stresses already overburdened health systems. A…
Dynamic Factor Analysis with Dependent Gaussian Processes for High-Dimensional Gene Expression Trajectories
Jiachen Cai, Robert J. B. Goudie, Colin Starr +1
The increasing availability of high-dimensional, longitudinal measures of gene expression can facilitate understanding of biological mechanisms, as required for precision medicine.…
Trends in COVID-19 hospital outcomes in England before and after vaccine introduction, a cohort study
Peter Kirwan, Andre Charlett, Paul Birrell +5
Widespread vaccination campaigns have changed the landscape for COVID-19, vastly altering symptoms and reducing morbidity and mortality. We estimate trends in mortality by month of…
Bayesian multistate modelling of incomplete chronic disease burden data
Christopher Jackson, Belen Zapata-Diomedi, James Woodcock
A widely-used model for determining the long-term health impacts of public health interventions, often called a "multistate lifetable", requires estimates of incidence, case fatali…
Hospitalisation risk for COVID-19 patients infected with SARS-CoV-2 variant B.1.1.7: cohort analysis
Tommy Nyberg, Katherine A. Twohig, Ross J. Harris +7
Objective: To evaluate the relationship between coronavirus disease 2019 (COVID-19) diagnosis with SARS-CoV-2 variant B.1.1.7 (also known as Variant of Concern 202012/01) and the r…
Adding experimental treatment arms to Multi-Arm Multi-Stage platform trials in progress
Thomas Burnett, Franz König, Thomas Jaki
Multi-Arm Multi-Stage (MAMS) platform trials are an efficient tool for the comparison of several treatments. Suppose we wish to add a treatment to a trial already in progress, to a…
A review of Bayesian perspectives on sample size derivation for confirmatory trials
Kevin Kunzmann, Michael J. Grayling, Kim May Lee +3
Sample size derivation is a crucial element of the planning phase of any confirmatory trial. A sample size is typically derived based on constraints on the maximal acceptable type…
Calculating the Expected Value of Sample Information in Practice: Considerations from Three Case Studies
Anna Heath, Natalia R. Kunst, Christopher Jackson +6
Investing efficiently in future research to improve policy decisions is an important goal. Expected Value of Sample Information (EVSI) can be used to select the specific design and…
Estimating the association between blood pressure variability and cardiovascular disease: An application using the ARIC Study
Jessica K. Barrett, Raphael Huille, Richard Parker +2
The association between visit-to-visit systolic blood pressure variability and cardiovascular events has recently received a lot of attention in the cardiovascular literature. But…
Exploiting routinely collected severe case data to monitor and predict influenza outbreaks
Alice Corbella, Xu-Sheng Zhang, Paul J. Birrell +4
Influenza remains a significant burden on health systems. Effective responses rely on the timely understanding of the magnitude and the evolution of an outbreak. For monitoring pur…
Value of Information: Sensitivity Analysis and Research Design in Bayesian Evidence Synthesis
Christopher Jackson, Anne Presanis, Stefano Conti +1
Suppose we have a Bayesian model which combines evidence from several different sources. We want to know which model parameters most affect the estimate or decision from the model,…
The coordinate-based meta-analysis of neuroimaging data
Pantelis Samartsidis, Silvia Montagna, Thomas E. Nichols +1
Neuroimaging meta-analysis is an area of growing interest in statistics. The special characteristics of neuroimaging data render classical meta-analysis methods inapplicable and th…
Using Ecological Propensity Score to Adjust for Missing Confounders in Small Area Studies
Yingbo Wang, Sylvia Richardson, Anna Hansell +1
Small area ecological studies are commonly used in epidemiology to assess the impact of area level risk factors on health outcomes when data are only available in an aggregated for…
Modelling collinear and spatially correlated data
Silvia Liverani, Aurore Lavigne, Marta Blangiardo
In this work we present a statistical approach to distinguish and interpret the complex relationship between several predictors and a response variable at the small area level, in…
Maximum likelihood and pseudo score approaches for parametric time-to-event analysis with informative entry times
Brian D. M. Tom, Vernon T. Farewell, Sheila M. Bird
We develop a maximum likelihood estimating approach for time-to-event Weibull regression models with outcome-dependent sampling, where sampling of subjects is dependent on the resi…
Reconstructing transmission trees for communicable diseases using densely sampled genetic data
Colin J. Worby, Philip D. O'Neill, Theodore Kypraios +5
Whole genome sequencing of pathogens from multiple hosts in an epidemic offers the potential to investigate who infected whom with unparalleled resolution, potentially yielding imp…
HIV dynamics and natural history studies: Joint modeling with doubly interval-censored event time and infrequent longitudinal data
Li Su, Joseph W. Hogan
Hepatitis C virus (HCV) coinfection has become one of the most challenging clinical situations to manage in HIV-infected patients. Recently the effect of HCV coinfection on HIV dyn…
Discussion of: Statistical analysis of an archeological find--skeptical counting challenges to an archaeological find
Sheila M. Bird
Discussion of ``Statistical analysis of an archeological find'' by Andrey Feuerverger [arXiv:0804.0079]
Accounting for self-protective responses in randomized response data from a social security survey using the zero-inflated Poisson model
Maarten J. L. F. Cruyff, Ulf Böckenholt, Ardo van den Hout +1
In 2004 the Dutch Department of Social Affairs conducted a survey to assess the extent of noncompliance with social security regulations. The survey was conducted among 870 recipie…