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9 papers · 1 filter
Breaking the VE-cadherin bonds
Julie Gavard
Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial…
VE-cadherin and claudin-5: it takes two to tango
Julie Gavard, J Silvio Gutkind
Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emergi…
Ligand-Receptor Interactions
Pierre Bongrand
The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems. During the last f…
Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons
Haijun Tu, Philippe Rondard, Chanjuan Xu +5
gamma-aminobutyric acid type B (GABA(B)) receptor is an allosteric complex made of two subunits, GABA(B1) and GABA(B2). GABA(B2) plays a major role in the coupling to G protein whe…
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning
Philippe Rondard, Siluo Huang, Carine Monnier +9
The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is require…
How cells tiptoe on adhesive surfaces before sticking
Anne Pierres, Anne-Marie Benoliel, Dominique Touchard +1
Cell membranes are studded with protrusions that were thoroughly analyzed with electron microscopy. However, the nanometer-scale three-dimensional motions generated by cell membran…