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11 papers · 1 filter
Breaking the VE-cadherin bonds
Julie Gavard
Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial…
Comparison of Perron and Floquet eigenvalues in age structured cell division cycle models
Jean Clairambault, Stéphane Gaubert, Thomas Lepoutre
We study the growth rate of a cell population that follows an age-structured PDE with time-periodic coefficients. Our motivation comes from the comparison between experimental tumo…
VE-cadherin and claudin-5: it takes two to tango
Julie Gavard, J Silvio Gutkind
Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emergi…
Ligand-Receptor Interactions
Pierre Bongrand
The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems. During the last f…
Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons
Haijun Tu, Philippe Rondard, Chanjuan Xu +5
gamma-aminobutyric acid type B (GABA(B)) receptor is an allosteric complex made of two subunits, GABA(B1) and GABA(B2). GABA(B2) plays a major role in the coupling to G protein whe…
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning
Philippe Rondard, Siluo Huang, Carine Monnier +9
The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is require…