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22 papers · 1 filter
Increased hepatic PDGF-AA signaling mediates liver insulin resistance in obesity associated type 2 diabetes
Amar Abderrahmani, Loic Yengo, Robert Caiazzo +35
Type 2 diabetes (T2D) is closely linked with non-alcoholic fatty liver disease (NAFLD) and hepatic insulin resistance, but the involved mechanisms are still elusive. Using DNA meth…
Tensile rupture of medial arterial tissue studied by X-ray micro-tomography on stained samples
Clémentine Helfenstein-Didier, Damien Taïnoff, Julien Viville +3
Detailed characterization of damage and rupture mechanics of arteries is one the current challenges in vascular biomechanics, which requires developing suitable experimental approa…
Development and cytotoxic response of two proliferative MDA- MB-231 and non-proliferative SUM1315 three-dimensional cell culture models of triple-negative basal-like breast cancer cell lines
Clémence Dubois, Dufour Robin, Daumar Pierre +6
Triple-Negative Basal-Like tumors, representing 15 to 20% of breast cancers, are very aggressive and with poor prognosis. Targeted therapies have been developed extensively in prec…
Parallel transport in shape analysis: a scalable numerical scheme
Maxime Louis, Alexandre Bône, Benjamin Charlier +1
The analysis of manifold-valued data requires efficient tools from Riemannian geometry to cope with the computational complexity at stake. This complexity arises from the always-in…
Prediction of the progression of subcortical brain structures in Alzheimer's disease from baseline
Alexandre Bône, Maxime Louis, Alexandre Routier +5
We propose a method to predict the subject-specific longitudinal progression of brain structures extracted from baseline MRI, and evaluate its performance on Alzheimer's disease da…
Pairwise Ising model analysis of human cortical neuron recordings
Trang-Anh Nghiem, Olivier Marre, Alain Destexhe +1
During wakefulness and deep sleep brain states, cortical neural networks show a different behavior, with the second characterized by transients of high network activity. To investi…