Comparison of Perron and Floquet eigenvalues in age structured cell division cycle models

Abstract

We study the growth rate of a cell population that follows an age-structured PDE with time-periodic coefficients. Our motivation comes from the comparison between experimental tumor growth curves in mice endowed with intact or disrupted circadian clocks, known to exert their influence on the cell division cycle. We compare the growth rate of the model controlled by a time-periodic control on its coefficients with the growth rate of stationary models of the same nature, but with averaged coefficients. We firstly derive a delay differential equation which allows us to prove several inequalities and equalities on the growth rates. We also discuss about the necessity to take into account the structure of the cell division cycle for chronotherapy modeling. Numerical simulations illustrate the results.

26 pages

References in corpus (2)

• Analysis of a Population Model Structured by the Cells Molecular Content
• An inequality for the Perron and Floquet eigenvalues of monotone differential systems and age structured equations

Cited by in corpus (5)

• Ergodic behavior of non-conservative semigroups via generalized Doeblin's conditions
• Circadian rhythm and cell population growth
• Self-similarity in a General Aggregation-Fragmentation Problem ; Application to Fitness Analysis
• Non-linear eigenvalue problems arising from growth maximization of positive linear dynamical systems
• Optimization of an Amplification Protocol for Misfolded Proteins by using Relaxed Control