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15 papers · 1 filter
Genome-wide scan of 29,141 African Americans finds no evidence of selection since admixture
Gaurav Bhatia, Arti Tandon, Melinda C. Aldrich +44
We scanned through the genomes of 29,141 African Americans, searching for loci where the average proportion of African ancestry deviates significantly from the genome-wide average.…
Ancient human genomes suggest three ancestral populations for present-day Europeans
Iosif Lazaridis, Nick Patterson, Alissa Mittnik +117
We sequenced genomes from a 7,000 year old early farmer from Stuttgart in Germany, an 8,000 year old hunter-gatherer from Luxembourg, and seven 8,000 year old hun…
Response to a population bottleneck can be used to infer recessive selection
Daniel J. Balick, Ron Do, David Reich +1
Here we present the first genome wide statistical test for recessive selection. This test uses explicitly non-equilibrium demographic differences between populations to infer the m…
All-optical sensing of a single-molecule electron spin
A. O. Sushkov, N. Chisholm, I. Lovchinsky +8
We demonstrate an all-optical method for magnetic sensing of individual molecules in ambient conditions at room temperature. Our approach is based on shallow nitrogen-vacancy (NV)…
SMaSH: A Benchmarking Toolkit for Human Genome Variant Calling
Ameet Talwalkar, Jesse Liptrap, Julie Newcomb +7
Motivation: Computational methods are essential to extract actionable information from raw sequencing data, and to thus fulfill the promise of next-generation sequencing technology…
Fast and accurate imputation of summary statistics enhances evidence of functional enrichment
Bogdan Pasaniuc, Noah Zaitlen, Huwenbo Shi +7
Imputation using external reference panels is a widely used approach for increasing power in GWAS and meta-analysis. Existing HMM-based imputation approaches require individual-lev…