32 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- University of HavanaCU6 papers
- Italian institute for Genomic MedicineIT4 papers
- Centro de Ingeniería Genética y BiotecnologíaCU3 papers
- Barcelona Institute of Science and TechnologyES1 paper
- Cancer Research UK Scotland InstituteGB1 paper
- Institució Catalana de Recerca i Estudis AvançatsES1 paper
- Institut Català de Nanociència i NanotecnologiaES1 paper
- Instituto de Cibernética Matemática y FísicaCU1 paper
- Istituto di NanotecnologiaIT1 paper
- National Research CouncilLK1 paper
- Norwegian University of Life SciencesNO1 paper
- Universidad Central "Marta Abreu" de las Villas (UCLV)CU1 paper
10 papers
On the gene expression landscape of cancer
Augusto Gonzalez, Yasser Perera, Rolando Perez
A principal component analysis of the TCGA data for 15 cancer localizations unveils the following qualitative facts about tumors: 1) The state of a tissue in gene expression space…
Spin Glass Theory of Interacting Metabolic Networks
Jorge Fernandez-de-Cossio-Diaz, Roberto Mulet
We cast the metabolism of interacting cells within a statistical mechanics framework considering both, the actual phenotypic capacities of each cell and its interaction with its ne…
Maximum entropy and population heterogeneity in continuous cell cultures
Jorge Fernandez-de-Cossio-Diaz, Roberto Mulet
Continuous cultures of mammalian cells are complex systems displaying hallmark phenomena of nonlinear dynamics, such as multi-stability, hysteresis, as well as sharp transitions be…
Cell population heterogeneity driven by stochastic partition and growth optimality
Jorge Fernandez-de-Cossio-Diaz, Roberto Mulet, Alexei Vazquez
A fundamental question in biology is how cell populations evolve into different subtypes based on homogeneous processes at the single cell level. Here we show that population bimod…
Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths
Y. B. Ruiz-Blanco, Y. Almeida, C. M. Sotomayor-Torres +1
Electrical forces are the background of all the interactions occurring in biochemical systems. From here and by using a combination of ab-initio and ad-hoc models, we introduce the…
Missing and spurious interaction in additive, multiplicative and odds ratio models
Jorge Fernandez-de-Cossio, Jorge Fernandez-de-Cossio-Diaz, Toshifumi Takao +1
Additive, multiplicative, and odd ratio neutral models for interactions are for long advocated and controversial in epidemiology. We show here that these commonly advocated models…
Characterizing steady states of genome-scale metabolic networks in continuous cell cultures
Jorge Fernandez-de-Cossio-Diaz, Kalet León, Roberto Mulet
We present a model for continuous cell culture coupling intra-cellular metabolism to extracellular variables describing the state of the bioreactor, taking into account the growth…
Genetic interactions from first principles
Jorge Fernandez-de-Cossio, Jorge Fernandez-de-Cossio-Diaz, Yasser Perera
We derive a general statistical model of interactions, starting from probabilistic principles and elementary requirements. Prevailing interaction models in biomedical researches di…
Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype
Jorge Fernandez-de-Cossio-Diaz, Andrea De Martino, Roberto Mulet
We introduce an in silico model for the initial spread of an aberrant phenotype with Warburg-like overflow metabolism within a healthy homeostatic tissue in contact with a nutrient…
Fast inference of ill-posed problems within a convex space
Jorge Fernandez-de-Cossio-Diaz, Roberto Mulet
In multiple scientific and technological applications we face the problem of having low dimensional data to be justified by a linear model defined in a high dimensional parameter s…