4 papers
Missing and spurious interaction in additive, multiplicative and odds ratio models
Jorge Fernandez-de-Cossio, Jorge Fernandez-de-Cossio-Diaz, Toshifumi Takao +1
Additive, multiplicative, and odd ratio neutral models for interactions are for long advocated and controversial in epidemiology. We show here that these commonly advocated models…
Genetic interactions from first principles
Jorge Fernandez-de-Cossio, Jorge Fernandez-de-Cossio-Diaz, Yasser Perera
We derive a general statistical model of interactions, starting from probabilistic principles and elementary requirements. Prevailing interaction models in biomedical researches di…
Impact of germline susceptibility variants in cancer genetic studies
Jorge Fernandez-de-Cossio, Yasser Perera
Although somatic mutations are the main contributor to cancer, underlying germline alterations may increase the risk of cancer, mold the somatic alteration landscape and cooperate…
Maximum entropy method: sampling bias
Jorge Fernandez-de-Cossio, Jorge Fernandez-de-Cossio Diaz
Maximum entropy method is a constructive criterion for setting up a probability distribution maximally non-committal to missing information on the basis of partial knowledge, usual…