23 citations · 58 across the 13 of their papers we have counts for
13 papers
Face morphometric profiles of groups as early markers for certain diseases?
Roberto Herrero, Yoanna Martinez-Diaz, Heydi Mendez-Vazquez +2
Background: Face morphometry has been shown to work as a diagnosis tool in a set of syndromes. Face similarities are usually indications of more complete genetic similarities. Purp…
Average fold-change of genetic pathways in biological transitions
Sandra Costa, Joan Nieves, Augusto Gonzalez
A biological transition from a state N to a state T is characterized by a rearrangement of the gene expression profile in the system, quantitatively measured through the differenti…
Estimating the number of available states for normal and tumor tissues in gene expression space
Augusto Gonzalez, Frank Quintela, Dario A. Leon +2
The topology of gene expression space for a set of 12 cancer types is studied by means of an entropy-like magnitude, which allows the characterization of the regions occupied by tu…
On the gene expression landscape of cancer
Augusto Gonzalez, Yasser Perera, Rolando Perez
A principal component analysis of the TCGA data for 15 cancer localizations unveils the following qualitative facts about tumors: 1) The state of a tissue in gene expression space…
Modeling evolution in a Long Time Evolution Experiment with E. Coli
Dario A. Leon, Augusto Gonzalez
Taking into account an evolutionary model of mutations in term of Levy Fights that was previously constructed, we designed an algorithm to reproduce the evolutionary dynamics of th…
Constraint on the stem cell numbers and division rates posed by the risk of cancer
Augusto Gonzalez, Teresita Rodriguez, Rolando Perez
Compiled data for the stem cell numbers, Ns, and division rates, ms, is reanalized in order to show that we can distinguish two groups of human tissues. In the first one, there is…
Gene expression rearrangements denoting changes in the biological state
Augusto Gonzalez, Joan Nieves, Maria Luisa Bringas Vega +1
In many situations, the gene expression signature is a unique marker of the biological state. We study the modification of the gene expression distribution function when the biolog…
Symmetries of Coefficients of Three-Term Relations for the Hypergeometric Series
Yuka Yamaguchi
Any three hypergeometric series whose respective parameters, a, b and c, differ by integers satisfy a linear relation with coefficients that are rational functions of a, b, c and t…
Estimating the number of tissue resident macrophages
Augusto Gonzalez
I provide a simple estimation for the number of macrophages in a tissue, arising from the hypothesis that they should keep infections below a certain threshold, above which neutrop…
Mathematical control theory, the immune system, and cancer
Augusto Gonzalez
Simple ideas, endowed from the mathematical theory of control, are used in order to analyze in general grounds the human immune system. The general principles are minimization of t…
The long-tail distribution function of mutations in bacteria
Augusto Gonzalez
Levy flights in the space of mutations model time evolution of bacterial DNA. Parameters in the model are adjusted in order to fit observations coming from the Long Time Evolution…
Levy model of cancer
Roberto Herrero, Dario A. Leon, Augusto Gonzalez
A small portion of a tissue defines a microstate in gene expression space. Mutations, epigenetic events or external factors cause microstate displacements which are modeled by comb…
Mutagenesis and Background Neutron Radiation
Augusto Gonzalez
We suggest a possible correlation between the ionization events caused by the background neutron radiation and the experimental data on mutations with damage in the DNA repair mech…