23 citations · 58 across the 13 of their papers we have counts for
6 papers · 1 filter
Average fold-change of genetic pathways in biological transitions
Sandra Costa, Joan Nieves, Augusto Gonzalez
A biological transition from a state N to a state T is characterized by a rearrangement of the gene expression profile in the system, quantitatively measured through the differenti…
Estimating the number of available states for normal and tumor tissues in gene expression space
Augusto Gonzalez, Frank Quintela, Dario A. Leon +2
The topology of gene expression space for a set of 12 cancer types is studied by means of an entropy-like magnitude, which allows the characterization of the regions occupied by tu…
On the gene expression landscape of cancer
Augusto Gonzalez, Yasser Perera, Rolando Perez
A principal component analysis of the TCGA data for 15 cancer localizations unveils the following qualitative facts about tumors: 1) The state of a tissue in gene expression space…
Constraint on the stem cell numbers and division rates posed by the risk of cancer
Augusto Gonzalez, Teresita Rodriguez, Rolando Perez
Compiled data for the stem cell numbers, Ns, and division rates, ms, is reanalized in order to show that we can distinguish two groups of human tissues. In the first one, there is…
Estimating the number of tissue resident macrophages
Augusto Gonzalez
I provide a simple estimation for the number of macrophages in a tissue, arising from the hypothesis that they should keep infections below a certain threshold, above which neutrop…
Mathematical control theory, the immune system, and cancer
Augusto Gonzalez
Simple ideas, endowed from the mathematical theory of control, are used in order to analyze in general grounds the human immune system. The general principles are minimization of t…