activity
20172026
most citedCharacterizing steady states of genome-scale metabolic networks in continuous cell cultures

32 citations · 49 across the 7 of their papers we have counts for

collaborators

12 papers

cs.LG2026

Spherical Boltzmann machines: a solvable theory of learning and generation in energy-based models

Thomas Tulinski, Simona Cocco, Rémi Monasson +1

Energy-based models (EBMs) are flexible generative architectures inspired by statistical physics, but their learning and generative properties remain poorly understood. Here, we an…

cond-mat.dis-nn2026

Replica Theory of Spherical Boltzmann Machine Ensembles

Thomas Tulinski, Jorge Fernandez-De-Cossio-Diaz, Simona Cocco +1

Training in machine learning generally consists in finding one model, whose parameters minimize a data-dependent loss. Yet, empirical work shows that ensemble learning, an approach…

q-bio.PE2025

A High-Order Cumulant Extension of Quasi-Linkage Equilibrium

Kai S. Shimagaki, Jorge Fernandez-de-Cossio-Diaz, Mauro Pastore +3

A central question in evolutionary biology is how to quantitatively understand the dynamics of genetically diverse populations. Modeling the genotype distribution is challenging, a…

cs.LG2022★ 17 cited

Disentangling representations in Restricted Boltzmann Machines without adversaries

Jorge Fernandez-de-Cossio-Diaz, Simona Cocco, Remi Monasson

A goal of unsupervised machine learning is to build representations of complex high-dimensional data, with simple relations to their properties. Such disentangled representations m…

cond-mat.stat-mech2021

Inferring metabolic fluxes in nutrient-limited continuous cultures: A Maximum Entropy Approach with minimum information

Jose A. Pereiro-Morejón, Jorge Fernández-de-Cossio-Díaz, R. Mulet

We propose a new scheme to infer the metabolic fluxes of cell cultures in a chemostat. Our approach is based on the Maximum Entropy Principle and exploits the understanding of the…

q-bio.MN2019

Spin Glass Theory of Interacting Metabolic Networks

Jorge Fernandez-de-Cossio-Diaz, Roberto Mulet

We cast the metabolism of interacting cells within a statistical mechanics framework considering both, the actual phenotypic capacities of each cell and its interaction with its ne…