554 citations · 1.1k across the 3 of their papers we have counts for
5 papers
Kinetics of protein-DNA interaction: facilitated target location in sequence-dependent potential
Michael Slutsky, Leonid A. Mirny
Recognition and binding of specific sites on DNA by proteins is central for many cellular functions such as transcription, replication, and recombination. In the process of recogni…
The long reach of DNA sequence heterogeneity in diffusive processes
Michael Slutsky, Mehran Kardar, Leonid A. Mirny
Many biological processes involve one dimensional diffusion over a correlated inhomogeneous energy landscape with a correlation length . Typical examples are specific protein…
Virus shapes and buckling transitions in spherical shells
Jack Lidmar, Leonid Mirny, David R. Nelson
We show that the icosahedral packings of protein capsomeres proposed by Caspar and Klug for spherical viruses become unstable to faceting for sufficiently large virus size, in anal…
Evolutionary conservation of the folding nucleus
Leonid Mirny, Eugene Shakhnovich
In this Communication we present statistical analysis of conservation profiles in families of homologous sequences for nine proteins whose folding nucleus was determined by protein…
Understanding conserved amino acids in proteins
Nikolay V. Dokholyan, Leonid A. Mirny, Eugene I. Shakhnovich
It has been conjectured that evolution exerted pressure to preserve amino acids bearing thermodynamic, kinetic, and functional roles. In this letter we show that the physical requi…