554 citations · 2.4k across the 15 of their papers we have counts for
16 papers
Effects of topological constraints on globular polymers
Maxim Imakaev, Konstantin Tchourine, Sergei Nechaev +1
Topological constraints can affect both equilibrium and dynamic properties of polymer systems, and can play a role in the organization of chromosomes. Despite many theoretical stud…
Chromatin Loops as Allosteric Modulators of Enhancer-Promoter Interactions
Boryana Doyle, Geoffrey Fudenberg, Maxim Imakaev +1
The classic model of eukaryotic gene expression requires direct spatial contact between a distal enhancer and a proximal promoter. Recent Chromosome Conformation Capture (3C) studi…
A tug-of-war between driver and passenger mutations in cancer and other adaptive processes
Christopher McFarland, Leonid Mirny, Kirill S. Korolev
Cancer progression is an example of a rapid adaptive process where evolving new traits is essential for survival and requires a high mutation rate. Precancerous cells acquire a few…
The impact of deleterious passenger mutations on cancer progression
Christopher D McFarland, Gregory V Kryukov, Shamil Sunyaev +1
Cancer progression is driven by a small number of genetic alterations accumulating in a neoplasm. These few driver alterations reside in a cancer genome alongside tens of thousands…
High-order chromatin architecture determines the landscape of chromosomal alterations in cancer
Geoff Fudenberg, Gad Getz, Matthew Meyerson +1
The rapid growth of cancer genome structural information provides an opportunity for a better understanding of the mutational mechanisms of genomic alterations in cancer and the fo…
Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs
Leonid A. Mirny, Zeba Wunderlich
To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6-10^9 decoy site…