554 citations · 2.4k across the 15 of their papers we have counts for
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Chromatin Loops as Allosteric Modulators of Enhancer-Promoter Interactions
Boryana Doyle, Geoffrey Fudenberg, Maxim Imakaev +1
The classic model of eukaryotic gene expression requires direct spatial contact between a distal enhancer and a proximal promoter. Recent Chromosome Conformation Capture (3C) studi…
High-order chromatin architecture determines the landscape of chromosomal alterations in cancer
Geoff Fudenberg, Gad Getz, Matthew Meyerson +1
The rapid growth of cancer genome structural information provides an opportunity for a better understanding of the mutational mechanisms of genomic alterations in cancer and the fo…
Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs
Leonid A. Mirny, Zeba Wunderlich
To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6-10^9 decoy site…