554 citations · 2.4k across the 15 of their papers we have counts for
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2 papers · 1 filter
q-bio.PE2014★ 174 cited
A tug-of-war between driver and passenger mutations in cancer and other adaptive processes
Christopher McFarland, Leonid Mirny, Kirill S. Korolev
Cancer progression is an example of a rapid adaptive process where evolving new traits is essential for survival and requires a high mutation rate. Precancerous cells acquire a few…
q-bio.PE2012★ 355 cited
The impact of deleterious passenger mutations on cancer progression
Christopher D McFarland, Gregory V Kryukov, Shamil Sunyaev +1
Cancer progression is driven by a small number of genetic alterations accumulating in a neoplasm. These few driver alterations reside in a cancer genome alongside tens of thousands…