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physics.bio-ph2000
Evolutionary conservation of the folding nucleus
Leonid Mirny, Eugene Shakhnovich
In this Communication we present statistical analysis of conservation profiles in families of homologous sequences for nine proteins whose folding nucleus was determined by protein…
cond-mat.stat-mech2000
Understanding conserved amino acids in proteins
Nikolay V. Dokholyan, Leonid A. Mirny, Eugene I. Shakhnovich
It has been conjectured that evolution exerted pressure to preserve amino acids bearing thermodynamic, kinetic, and functional roles. In this letter we show that the physical requi…