554 citations · 2.4k across the 15 of their papers we have counts for
3 papers · 1 filter
Operating Regimes of Signaling Cycles: Statics, Dynamics, and Noise Filtering
Carlos Gomez-Uribe, George C. Verghese, Leonid A. Mirny
A ubiquitous building block of signaling pathways is a cycle of covalent modification (e.g., phosphorylation and dephosphorylation in MAPK cascades). Our paper explores the kind of…
Spatial effects on the speed and reliability of protein-DNA search
Zeba Wunderlich, Leonid A. Mirny
Strong experimental and theoretical evidence shows that transcription factors and other specific DNA-binding proteins find their sites using a two-mode search: alternating between…
Intricate Knots in Proteins: Function and Evolution
Peter Virnau, Leonid A. Mirny, Mehran Kardar
A number of recently discovered protein structures incorporate a rather unexpected structural feature: a knot in the polypeptide backbone. These knots are extremely rare, but their…