4 citations · 5 across the 9 of their papers we have counts for
3 papers · 2 filters
A Bayesian time-to-event pharmacokinetic model for sequential phase I dose-escalation trials with multiple schedules
Burak Kürsad Günhan, Sebastian Weber, Abdelkader Seroutou +1
Phase I dose-escalation trials constitute the first step in investigating the safety of potentially promising drugs in humans. Conventional methods for phase I dose-escalation tria…
Recent advances in methodology for clinical trials in small populations: the InSPiRe project
T. Friede, M. Posch, S. Zohar +19
Where there are a limited number of patients, such as in a rare disease, clinical trials in these small populations present several challenges, including statistical issues. This l…
Meta-analysis of few studies involving rare events
Burak Kürsad Günhan, Christian Röver, Tim Friede
Meta-analyses of clinical trials targeting rare events face particular challenges when the data lack adequate numbers of events for all treatment arms. Especially when the number o…