8 citations · 13 across the 8 of their papers we have counts for
17 papers
Quasispecies can exist under neutral drift at finite population sizes
Robert Forster, Christoph Adami, Claus O. Wilke
We investigate the evolutionary dynamics of a finite population of RNA sequences adapting to a neutral fitness landscape. Despite the lack of differential fitness between viable se…
A single determinant for the rate of yeast protein evolution
D. Allan Drummond, Alpan Raval, Claus O. Wilke
A gene's rate of sequence evolution is among the most fundamental evolutionary quantities in common use, but what determines evolutionary rates has remained unclear. Here, we show…
Replication at periodically changing multiplicity of infection promotes stable coexistence of competing viral populations
Claus O. Wilke, Daniel D. Reissig, Isabel S. Novella
RNA viruses are a widely used tool to study evolution experimentally. Many standard protocols of virus propagation and competition are done at nominally low multiplicity of infecti…
The Speed of Adaptation in Large Asexual Populations
Claus O. Wilke
In large asexual populations, beneficial mutations have to compete with each other for fixation. Here, I derive explicit analytic expressions for the rate of substitution and the m…
Modeling stochastic clonal interference
Paulo R. A. Campos, Christoph Adami, Claus O. Wilke
We study the competition between several advantageous mutants in an asexual population (clonal interference) as a function of the time between the appearance of the mutants, their…
Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding
Claus O Wilke, Richard E Lenski, Christoph Adami
Background: The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level…