8 citations · 13 across the 8 of their papers we have counts for
10 papers · 1 filter
Modeling stochastic clonal interference
Paulo R. A. Campos, Christoph Adami, Claus O. Wilke
We study the competition between several advantageous mutants in an asexual population (clonal interference) as a function of the time between the appearance of the mutants, their…
Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding
Claus O Wilke, Richard E Lenski, Christoph Adami
Background: The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level…
Does the Red Queen reign in the kingdom of digital organisms?
Claus O. Wilke
In competition experiments between two RNA viruses of equal or almost equal fitness, often both strains gain in fitness before one eventually excludes the other. This observation h…
Finite genome size can halt Muller's ratchet
Tor Schoenmeyr, Claus O. Wilke
We study the accumulation of deleterious mutations in a haploid, asexually reproducing population, using analytical models and computer simulations. We find that Muller's ratchet c…
Selection for Fitness vs. Selection for Robustness in RNA Secondary Structure Folding
Claus O. Wilke
We investigate the competition between two quasispecies residing on two disparate neutral networks. Under the assumption that the two neutral networks have different topologies and…
Adaptive evolution on neutral networks
Claus O. Wilke
We study the evolution of large but finite asexual populations evolving in fitness landscapes in which all mutations are either neutral or strongly deleterious. We demonstrate that…