587 citations · 1.4k across the 36 of their papers we have counts for
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Dissecting the roles of local packing density and longer-range effects in protein sequence evolution
Amir Shahmoradi, Claus Wilke
What are the structural determinants of protein sequence evolution? A number of site-specific structural characteristics have been proposed, most of which are broadly related to ei…
Predicting evolutionary site variability from structure in viral proteins: buriedness, packing, flexibility, and design
Amir Shahmoradi, Dariya K. Sydykova, Stephanie J. Spielman +4
Several recent works have shown that protein structure can predict site-specific evolutionary sequence variation. In particular, sites that are buried and/or have many contacts wit…
Modeling stochastic clonal interference
Paulo R. A. Campos, Christoph Adami, Claus O. Wilke
We study the competition between several advantageous mutants in an asexual population (clonal interference) as a function of the time between the appearance of the mutants, their…
Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding
Claus O Wilke, Richard E Lenski, Christoph Adami
Background: The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level…
Does the Red Queen reign in the kingdom of digital organisms?
Claus O. Wilke
In competition experiments between two RNA viruses of equal or almost equal fitness, often both strains gain in fitness before one eventually excludes the other. This observation h…
Probability of fixation of an advantageous mutant in a viral quasispecies
Claus O. Wilke
The probability that an advantageous mutant rises to fixation in a viral quasispecies is investigated in the framework of multi-type branching processes. Whether fixation is possib…