587 citations · 1.4k across the 36 of their papers we have counts for
9 papers · 1 filter
The look-ahead effect of phenotypic mutations
Dion J. Whitehead, Claus O. Wilke, David Vernazobres +1
The evolution of complex molecular traits such as disulphide bridges often requires multiple mutations. The intermediate steps in such evolutionary trajectories are likely to be se…
The traveling wave approach to asexual evolution: Muller's ratchet and speed of adaptation
Igor M. Rouzine, Eric Brunet, Claus O. Wilke
We use traveling-wave theory to derive expressions for the rate of accumulation of deleterious mutations under Muller's ratchet and the speed of adaptation under positive selection…
The stochastic edge in adaptive evolution
Eric Brunet, Igor M. Rouzine, Claus O. Wilke
In a recent article, Desai and Fisher (2007) proposed that the speed of adaptation in an asexual population is determined by the dynamics of the stochastic edge of the population,…
Thermodynamics of Neutral Protein Evolution
Jesse D Bloom, Alpan Raval, Claus O Wilke
Naturally evolving proteins gradually accumulate mutations while continuing to fold to thermodynamically stable native structures. This process of neutral protein evolution is an i…
Quasispecies can exist under neutral drift at finite population sizes
Robert Forster, Christoph Adami, Claus O. Wilke
We investigate the evolutionary dynamics of a finite population of RNA sequences adapting to a neutral fitness landscape. Despite the lack of differential fitness between viable se…
A single determinant for the rate of yeast protein evolution
D. Allan Drummond, Alpan Raval, Claus O. Wilke
A gene's rate of sequence evolution is among the most fundamental evolutionary quantities in common use, but what determines evolutionary rates has remained unclear. Here, we show…