96 citations · 617 across the 17 of their papers we have counts for
17 papers
Promises and Challenges in Continuous Tracking Utilizing Amino Acids in Skin Secretions for Active Multi-Factor Biometric Authentication for Cybersecurity
Juliana Agudelo, Vladimir Privman, Jan Halamek
We consider a new concept of biometric-based cybersecurity systems for active authentication by continuous tracking, which utilizes biochemical processing of metabolites present in…
Networked Enzymatic Logic Gates with Filtering: New Theoretical Modeling Expressions and Their Experimental Application
Vladimir Privman, Oleksandr Zavalov, Lenka Halamkova +3
We report the first study of a network of connected enzyme-catalyzed reactions, with added chemical and enzymatic processes that incorporate the recently developed biochemical filt…
Enzymatic AND Logic Gate with Sigmoid Response Induced by Photochemically Controlled Oxidation of the Output
Vladimir Privman, Brian E. Fratto, Oleksandr Zavalov +2
We report a study of a system which involves an enzymatic cascade realizing an AND logic gate, with an added photochemical processing of the output allowing to make the gate's resp…
Modularity of Biochemical Filtering for Inducing Sigmoid Response in Both Inputs in an Enzymatic AND Gate
Saira Bakshi, Oleksandr Zavalov, Jan Halamek +2
We report the first systematic study of designed two-input biochemical systems as information processing gates with favorable noise-transmission properties accomplished by modifyin…
Bioinspired Associative Memory System Based on Enzymatic Cascades
Kevin MacVittie, Jan Halamek, Vladimir Privman +1
A biomolecular system representing the first realization of associative memory based on enzymatic reactions in vitro has been designed. The system demonstrated "training" and "forg…
Two-Input Enzymatic Logic Gates Made Sigmoid by Modifications of the Biocatalytic Reaction Cascades
Oleksandr Zavalov, Vera Bocharova, Jan Halamek +6
Computing based on biochemical processes is a newest rapidly developing field of unconventional information and signal processing. In this paper we present results of our research…
A Biochemical Logic Approach to Biomarker-Activated Drug Release
V. Bocharova, O. Zavalov, K. MacVittie +7
The present study aims at integrating drug-releasing materials with signal-processing biocomputing systems. Enzymes alanine transaminase (ALT) and aspartate transaminase (AST)---bi…
Realization of Associative Memory in an Enzymatic Process: Towards Biomolecular Networks with Learning and Unlearning Functionalities
Vera Bocharova, Kevin MacVittie, Soujanya Chinnapareddy +3
We report a realization of an associative memory signal/information processing system based on simple enzyme-catalyzed biochemical reactions. Optically detected chemical output is…
Enzyme-Based Logic Analysis of Biomarkers at Physiological Concentrations: AND Gate with Double-Sigmoid "Filter" Response
Jan Halamek, Oleksandr Zavalov, Lenka Halamkova +3
We report the first realization of a biomolecular AND gate function with double-sigmoid response (sigmoid in both inputs). Two enzyme biomarker inputs activate the gate output sign…
Biomolecular Filters for Improved Separation of Output Signals in Enzyme Logic Systems Applied to Biomedical Analysis
Jan Halamek, Jian Zhou, Lenka Halamkova +4
Biomolecular logic systems processing biochemical input signals and producing "digital" outputs in the form of YES/NO were developed for analysis of physiological conditions charac…
Realization and Properties of Biochemical-Computing Biocatalytic XOR Gate Based on Enzyme Inhibition by a Substrate
Jan Halamek, Vera Bocharova, Mary A. Arugula +3
We consider a realization of the XOR logic gate in a process biocatalyzed by an enzyme (here horseradish peroxidase: HRP), the function of which can be inhibited by a substrate (hy…
Biochemical Filter with Sigmoidal Response: Increasing the Complexity of Biomolecular Logic
Vladimir Privman, Jan Halamek, Mary A. Arugula +3
The first realization of a designed, rather than natural, biochemical filter process is reported and analyzed as a promising network component for increasing the complexity of biom…
Realization and Properties of Biochemical-Computing Biocatalytic XOR Gate Based on Signal Change
Vladimir Privman, Jian Zhou, Jan Halamek +1
We consider a realization of the XOR logic gate in a system involving two competing biocatalytic reactions, for which the logic-1 output is defined by these two processes causing a…
Enzymatic AND Logic Gates Operated Under Conditions Characteristic of Biomedical Applications
Dmitriy Melnikov, Guinevere Strack, Jian Zhou +8
Experimental and theoretical analyses of the lactate dehydrogenase and glutathione reductase based enzymatic AND logic gates in which the enzymes and their substrates serve as logi…
Enzymatic Logic Gates with Noise-Reducing Sigmoid Response
Valber Pedrosa, Dmitriy Melnikov, Marcos Pita +4
Biochemical computing is an emerging field of unconventional computing that attempts to process information with biomolecules and biological objects using digital logic. In this wo…
Optimization of Enzymatic Logic Gates and Networks for Noise Reduction and Stability
Mary A. Arugula, Jan Halamek, Evgeny Katz +4
Biochemical computing attempts to process information with biomolecules and biological objects. In this work we review our results on analysis and optimization of single biochemica…
Network Analysis of Biochemical Logic for Noise Reduction and Stability: A System of Three Coupled Enzymatic AND Gates
Vladimir Privman, Mary A. Arugula, Jan Halamek +2
We develop an approach aimed at optimizing the parameters of a network of biochemical logic gates for reduction of the "analog" noise buildup. Experiments for three coupled enzymat…