96 citations · 617 across the 17 of their papers we have counts for
8 papers · 1 filter
Networked Enzymatic Logic Gates with Filtering: New Theoretical Modeling Expressions and Their Experimental Application
Vladimir Privman, Oleksandr Zavalov, Lenka Halamkova +3
We report the first study of a network of connected enzyme-catalyzed reactions, with added chemical and enzymatic processes that incorporate the recently developed biochemical filt…
Enzymatic AND Logic Gate with Sigmoid Response Induced by Photochemically Controlled Oxidation of the Output
Vladimir Privman, Brian E. Fratto, Oleksandr Zavalov +2
We report a study of a system which involves an enzymatic cascade realizing an AND logic gate, with an added photochemical processing of the output allowing to make the gate's resp…
Modularity of Biochemical Filtering for Inducing Sigmoid Response in Both Inputs in an Enzymatic AND Gate
Saira Bakshi, Oleksandr Zavalov, Jan Halamek +2
We report the first systematic study of designed two-input biochemical systems as information processing gates with favorable noise-transmission properties accomplished by modifyin…
Bioinspired Associative Memory System Based on Enzymatic Cascades
Kevin MacVittie, Jan Halamek, Vladimir Privman +1
A biomolecular system representing the first realization of associative memory based on enzymatic reactions in vitro has been designed. The system demonstrated "training" and "forg…
Two-Input Enzymatic Logic Gates Made Sigmoid by Modifications of the Biocatalytic Reaction Cascades
Oleksandr Zavalov, Vera Bocharova, Jan Halamek +6
Computing based on biochemical processes is a newest rapidly developing field of unconventional information and signal processing. In this paper we present results of our research…
A Biochemical Logic Approach to Biomarker-Activated Drug Release
V. Bocharova, O. Zavalov, K. MacVittie +7
The present study aims at integrating drug-releasing materials with signal-processing biocomputing systems. Enzymes alanine transaminase (ALT) and aspartate transaminase (AST)---bi…
Realization of Associative Memory in an Enzymatic Process: Towards Biomolecular Networks with Learning and Unlearning Functionalities
Vera Bocharova, Kevin MacVittie, Soujanya Chinnapareddy +3
We report a realization of an associative memory signal/information processing system based on simple enzyme-catalyzed biochemical reactions. Optically detected chemical output is…
Enzyme-Based Logic Analysis of Biomarkers at Physiological Concentrations: AND Gate with Double-Sigmoid "Filter" Response
Jan Halamek, Oleksandr Zavalov, Lenka Halamkova +3
We report the first realization of a biomolecular AND gate function with double-sigmoid response (sigmoid in both inputs). Two enzyme biomarker inputs activate the gate output sign…