Synchronization and enhanced catalysis of mechanically coupled enzymes

Abstract

We examine the stochastic dynamics of two enzymes that are mechanically coupled to each other, e.g., through an elastic substrate or a fluid medium. The enzymes undergo conformational changes during their catalytic cycle, which itself is driven by stochastic steps along a biased chemical free energy landscape. We find conditions under which the enzymes can synchronize their catalytic steps, and discover that the coupling can lead to a significant enhancement in their overall catalytic rate. Both effects can be understood as arising from a global bifurcation in the underlying dynamical system at sufficiently strong coupling. Our findings suggest that, despite their molecular scale, enzymes can be cooperative and improve their performance in metabolic clusters.

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Cited by in corpus (3)

• Time-correlation functions for odd Langevin systems
• Odd elasticity of a catalytic micromachine
• Catalysis-Induced Phase Separation and Autoregulation of Enzymatic Activity