Synthetic Mechanochemical Molecular Swimmer

Abstract

A minimal design for a molecular swimmer is proposed that is a based on a mechanochemical propulsion mechanism. Conformational changes are induced by electrostatic actuation when specific parts of the molecule temporarily acquire net charges through catalyzed chemical reactions involving ionic components. The mechanochemical cycle is designed such that the resulting conformational changes would be sufficient for achieving low Reynolds number propulsion. The system is analyzed within the recently developed framework of stochastic swimmers to take account of the noisy environment at the molecular scale. The swimming velocity of the device is found to depend on the concentration of the fuel molecule according to the Michaelis-Menten rule in enzymatic reactions.

4 pages, 3 figures

References in corpus (7)

• The hydrodynamics of swimming microorganisms
• Self-motile colloidal particles: from directed propulsion to random walk
• Propulsion of a molecular machine by asymmetric distribution of reaction--products
• Analytic results for the three-sphere swimmer at low Reynolds number
• A basic swimmer at low Reynolds number
• Mechanical Response of a Small Swimmer Driven by Conformational Transitions
• A simple self-organized swimmer driven by molecular motors

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