Nonlinear response theory of molecular machines

Abstract

Chemical affinities are responsible for driving active matter systems out of equilibrium. At the nano-scale, molecular machines interact with the surrounding environment and are subjected to external forces. The mechano-chemical coupling which arises naturally in these systems reveals a complex interplay between chemical and mechanical degrees of freedom with strong impact on their active mechanism. By considering various models far from equilibrium, we show that the tuning of applied forces give rise to a nonlinear response that causes a non-monotonic behaviour in the machines' activity. Our findings have implications in understanding, designing, and triggering such processes by controlled application of external fields, including the collective dynamics of larger non-equilibrium systems where the total dissipation and performance might be affected by internal and inter-particle interactions.

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Cited by in corpus (4)

• Mechanistic rules for de novo design of enzymes
• Mechanical inhibition of dissipation in a thermodynamically consistent active solid
• Dumbbell dimer dynamics in three-dimensional chiral fluids
• Thermodynamic inference of correlations in nonequilibrium collective dynamics