194 citations · 1.1k across the 37 of their papers we have counts for
38 papers
Curvature-induced migration of small domains on lipid membranes
Jaime Agudo-Canalejo
Membrane curvature has been shown to bias the location of lipid or protein domains, but the roles of bending rigidity, spontaneous curvature, Gaussian bending modulus, and line ten…
An interdimensional funnel enhances topologically protected oscillations in high-dimensional stochastic systems
Varsha Traynor, Jaime Agudo-Canalejo
Biochemical systems such as protein complexes often occupy configuration spaces whose dimensionality grows with the number of molecular components. Although usually viewed as an ob…
Robust Topologically Protected Edge Transport in Doubly Chiral Active Particles
Tristan Edwards, Maxim Nikolaev, Jaime Agudo-Canalejo
Using theory, simulation, and experiment, we introduce a new class of active particle which we term doubly chiral active Brownian particles (dcABPs), which show robust topologicall…
Spatial self-organization of enzymes in complex reaction networks
Vincent Ouazan-Reboul, Ramin Golestanian, Jaime Agudo-Canalejo
Living systems contain intricate biochemical networks whose structure is closely related to their function and allows them to exhibit robust behavior in the presence of external st…
Topological edge currents promote exploratory search in microtubule dynamic instability
Chongbin Zheng, Jaime Agudo-Canalejo, Jonathon Howard +1
Microtubules capture chromosomes during mitosis by stochastically switching between growth and shrinkage at catastrophe events. They display strikingly rich biochemistry and dynami…
Nonequilibrium protein complexes as molecular automata
Jan Kocka, Kabir Husain, Jaime Agudo-Canalejo
Biology stores information and computes at the molecular scale, yet the ways in which it does so are often distinct from human-engineered computers. Mapping biological computation…
Phase Coexistence in Nonreciprocal Quorum-Sensing Active Matter
Yu Duan, Jaime Agudo-Canalejo, Ramin Golestanian +1
Motility and nonreciprocity are two primary mechanisms for self-organization in active matter. In a recent study [Phys. Rev. Lett. 131, 148301 (2023)], we explored their joint infl…
Mechanistic rules for de novo design of enzymes
Michalis Chatzittofi, Jaime Agudo-Canalejo, Ramin Golestanian
Enzymes are nano-scale machines that have evolved to drive chemical reactions out of equilibrium in the right place at the right time. Given the complexity and specificity of enzym…
Thermodynamic inference of correlations in nonequilibrium collective dynamics
Michalis Chatzittofi, Ramin Golestanian, Jaime Agudo-Canalejo
The theory of stochastic thermodynamics has revealed many useful fluctuation relations, with the thermodynamic uncertainty relation (TUR) being a theorem of major interest. When ma…
Topological phases in discrete stochastic systems
Jaime Agudo-Canalejo, Evelyn Tang
Topological invariants have proved useful for analyzing emergent function as they characterize a property of the entire system, and are insensitive to local details, disorder, and…
Nonlinear response theory of molecular machines
Michalis Chatzittofi, Jaime Agudo-Canalejo, Ramin Golestanian
Chemical affinities are responsible for driving active matter systems out of equilibrium. At the nano-scale, molecular machines interact with the surrounding environment and are su…
Role of shape in particle-lipid membrane interactions: from surfing to full engulfment
Stijn van der Ham, Jaime Agudo-Canalejo, Hanumantha Rao Vutukuri
Understanding and manipulating the interactions between foreign bodies and cell membranes during endo- and phagocytosis is of paramount importance, not only for the fate of living…
Entropy production and thermodynamic inference for stochastic microswimmers
Michalis Chatzittofi, Jaime Agudo-Canalejo, Ramin Golestanian
The question of characterization of the degree of non-equilibrium activity in active matter systems is studied in the context of a stochastic microswimmer model driven by a chemica…
Topological phase locking in stochastic oscillators
Michalis Chatzittofi, Ramin Golestanian, Jaime Agudo-Canalejo
The dynamics of many nanoscale biological and synthetic systems such as enzymes and molecular motors are activated by thermal noise, and driven out-of-equilibrium by local energy d…
Enhanced diffusion of tracer particles in nonreciprocal mixtures
Anthony Benois, Marie Jardat, Vincent Dahirel +4
We study the diffusivity of a tagged particle in a binary mixture of Brownian particles with non-reciprocal interactions. Numerical simulations reveal that, for a broad class of in…
Dynamical pattern formation without self-attraction in quorum-sensing active matter: the interplay between nonreciprocity and motility
Yu Duan, Jaime Agudo-Canalejo, Ramin Golestanian +1
We study a minimal model involving two species of particles interacting via quorum-sensing rules. Combining simulations of the microscopic model and linear stability analysis of th…
Interaction-motif-based classification of self-organizing metabolic cycles
Vincent Ouazan-Reboul, Ramin Golestanian, Jaime Agudo-Canalejo
Particles that are catalytically-active and chemotactic can interact through the concentration fields upon which they act, which in turn may lead to wide-scale spatial self-organiz…
Network effects lead to self-organization in metabolic cycles of self-repelling catalysts
Vincent Ouazan-Reboul, Ramin Golestanian, Jaime Agudo-Canalejo
Mixtures of particles that interact through phoretic effects are known to aggregate if they belong to species that exhibit attractive self-interactions. We study self-organization…
Self-organization of primitive metabolic cycles due to non-reciprocal interactions
Vincent Ouazan-Reboul, Jaime Agudo-Canalejo, Ramin Golestanian
We study analytically and numerically a model metabolic cycle composed of an arbitrary number of species of catalytically active particles. Each species converts a substrate into a…
Collective synchronization of dissipatively-coupled noise-activated processes
Michalis Chatzittofi, Ramin Golestanian, Jaime Agudo-Canalejo
A system of two enzymes mechanically coupled to each other in a viscous medium was recently studied, and conditions for obtaining synchronization and an enhanced average rate of th…
Catalysis-Induced Phase Separation and Autoregulation of Enzymatic Activity
Matthew W. Cotton, Ramin Golestanian, Jaime Agudo-Canalejo
We present a thermodynamically consistent model describing the dynamics of a multi-component mixture where one enzyme component catalyzes a reaction between other components. We fi…
Molecular Diffusivity of Click Reaction Components: The Diffusion Enhancement Question
Nasrollah Rezaei-Ghaleh, Jaime Agudo-Canalejo, Christian Griesinger +1
Micrometer-sized objects are widely known to exhibit chemically-driven motility in systems away from equilibrium. Experimental observation of reaction-induced motility or enhanceme…
Comment on "Relative Diffusivities of Bound and Unbound Protein Can Control Chemotactic Directionality''
Jaime Agudo-Canalejo, Pierre Illien, Ramin Golestanian
This is a comment on a recently published paper in Langmuir: Mandal, N. S.; Sen, A. Relative Diffusivities of Bound and Unbound Protein Can Control Chemotactic Directionality. Lang…
Dynamics of Spontaneous Wrapping of Microparticles by Floppy Lipid Membranes
Hendrik T. Spanke, Jaime Agudo-Canalejo, Daniel Tran +2
Lipid membranes form the barrier between the inside and outside of cells and many of their subcompartments. As such, they bind to a wide variety of nano- and micrometer sized objec…