In vivo laser Doppler holography of the human retina

Abstract

The eye offers a unique opportunity for non-invasive exploration of cardiovascular diseases. Optical angiography in the retina requires sensitive measurements, which hinders conventional full-field laser Doppler imaging schemes. To overcome this limitation, we used digital holography to perform laser Doppler perfusion imaging of the human retina in vivo with near-infrared light. Wideband measurements of the beat frequency spectrum of optical interferograms recorded with a 39 kHz CMOS camera are analyzed by short-time Fourier transformation. Power Doppler images and movies drawn from the zeroth moment of the power spectrum density reveal blood flows in retinal and choroidal vessels over 512 $\times$ 512 pixels covering 2.4 $\times$ 2.4 mm${}^2$ on the retina with a 13 ms temporal resolution.

arXiv comment5 pages, 5 figures

References in corpus (3)

• Depolarization of backscattered linearly polarized light
• Holographic laser Doppler imaging of microvascular blood flow
• High speed optical holography of retinal blood flow

Cited by in corpus (7)

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• Waveform analysis of human retinal and choroidal blood flow with laser Doppler holography
• Retinal blood flow imaging with combined full-field swept-source optical coherence tomography and laser Doppler holography
• Reverse contrast laser Doppler holography for lower frame rate retinal and choroidal blood flow imaging
• Laser Doppler holography of the anterior segment for blood flow imaging, eye tracking, and transparency assessment
• Measuring choriocapillaris blood flow with laser Doppler optical coherence tomography
• Analysis of retinal and choroidal images measured by laser Doppler holography