Nonequilibrium dissipation in living oocytes

Abstract

Living organisms are inherently out-of-equilibrium systems. We employ new developments in stochastic energetics and rely on a minimal microscopic model to predict the amount of mechanical energy dissipated by such dynamics. Our model includes complex rheological effects and nonequilibrium stochastic forces. By performing active microrheology and tracking micron-sized vesicles in the cytoplasm of living oocytes, we provide unprecedented measurements of the spectrum of dissipated energy. We show that our model is fully consistent with the experimental data, and we use it to offer predictions for the injection and dissipation energy scales involved in active fluctuations.

5 pages, 2 figures

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Cited by in corpus (42)

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• Inferring dissipation from current fluctuations
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• Improved bounds on entropy production in living systems
• The Entropy Production of Ornstein-Uhlenbeck Active Particles: a path integral method for correlations
• Optimizing active work: Dynamical phase transitions, collective motion, and jamming
• Active mechanics reveal molecular-scale force kinetics in living oocytes
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• Nonequilibrium mode-coupling theory for dense active systems of self-propelled particles
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• Thermodynamic cycles with active matter
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• Collective motion in large deviations of active particles
• Extracting maximum power from active colloidal heat engines
• Quantitative analysis of non-equilibrium systems from short-time experimental data
• Non-Gaussian noise without memory in active matter
• Spatial fluctuations at vertices of epithelial layers: quantification of regulation by Rho pathway
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• Spectral fingerprints of non-equilibrium dynamics: The case of a Brownian gyrator
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• Anomalous diffusion in viscoelastic media with active force dipoles
• Transport and Energetics of Bacterial Rectification
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• Characteristic oscillations in frequency-resolved heat dissipation of linear time-delayed Langevin systems: Approach from the violation of the fluctuation-response relation
• Optimal power and efficiency of odd engines
• Inferring entropy production rate from partially observed Langevin dynamics under coarse-graining