Activity driven fluctuations in living cells

Abstract

We propose a model for the dynamics of a probe embedded in a living cell, where both thermal fluctuations and nonequilibrium activity coexist. The model is based on a confining harmonic potential describing the elastic cytoskeletal matrix, which undergoes random active hops as a result of the nonequilibrium rearrangements within the cell. We describe the probe's statistics and we bring forth quantities affected by the nonequilibrium activity. We find an excellent agreement between the predictions of our model and experimental results for tracers inside living cells. Finally, we exploit our model to arrive at quantitative predictions for the parameters characterizing nonequilibrium activity, such as the typical time scale of the activity and the amplitude of the active fluctuations.

6 pages, 4 figures

References in corpus (6)

• Microrheology, stress fluctuations and active behavior of living cells
• Subdiffusion and the cage effect studied near the colloidal glass transition
• Non-equilibrium mechanics and dynamics of motor activated gels
• Effective Temperature of Red Blood Cell Membrane Fluctuations
• Probing active forces via a fluctuation-dissipation relation: Application to living cells
• Energetics of active fluctuations in living cells

Cited by in corpus (60)

• How far from equilibrium is active matter?
• Broken detailed balance and non-equilibrium dynamics in living systems
• The statistical physics of active matter: from self-catalytic colloids to living cells
• Irreversibility in active matter systems: Fluctuation theorem and mutual information
• Entropy production in field theories without time reversal symmetry: Quantifying the non-equilibrium character of active matter
• Inferring dissipation from current fluctuations
• Time-(ir)reversibility in active matter: from micro to macro
• The Entropy Production of Ornstein-Uhlenbeck Active Particles: a path integral method for correlations
• Autonomous engines driven by active matter: Energetics and design principles
• Particle diffusion in active fluids is non-monotonic in size
• Active mechanics reveal molecular-scale force kinetics in living oocytes
• Activity controls fragility: A Random First Order Transition Theory for an active glass
• Dynamics of a polymer in an active and crowded environment
• Nonequilibrium mode-coupling theory for dense active systems of self-propelled particles
• Fluctuating motion in an active environment
• Nonequilibrium dissipation in living oocytes
• Modeling the dynamics of a tracer particle in an elastic active gel
• The active trap model
• How dissipation constrains fluctuations in nonequilibrium liquids: Diffusion, structure and biased interactions
• Noise-induced acceleration of single molecule kinesin-1
• Dynamics and escape of active particles in a harmonic trap
• Thermodynamics of emergent structure in active matter
• Thermodynamic uncertainty relation for underdamped Langevin systems driven by a velocity-dependent force
• Escape of a passive particle from activity-induced energy landscape: Emergence of slow and fast effective diffusion
• AOUP in the presence of Brownian noise: a perturbative approach
• Rapid-Prototyping a Brownian Particle in an Active Bath
• Exact position distribution of a harmonically-confined run-and-tumble particle in two dimensions
• Tracer dynamics in one dimensional gases of active or passive particles
• On the generalized Langevin equation for a Rouse bead in a nonequilibrium bath
• Non-Gaussian noise without memory in active matter
• Nonequilibirum steady state for harmonically-confined active particles
• Driven probe under harmonic confinement in a colloidal bath
• Evolutionary reinforcement learning of dynamical large deviations
• Direct evaluation of dynamical large-deviation rate functions using a variational ansatz
• Mechanochemical enzymes and protein machines as hydrodynamic force dipoles: The active dimer model
• Diffusion caused by two noises-active and thermal
• Creeping motion of a solid particle inside a spherical elastic cavity
• Spatial fluctuations at vertices of epithelial layers: quantification of regulation by Rho pathway
• Signatures of motor susceptibility in the dynamics of a tracer particle in an active gel
• Transport and Diffusion Enhancement in Experimentally Realized Non-Gaussian Correlated Ratchets
• First passage time distribution of active thermal particles in potentials
• Anomalous diffusion in viscoelastic media with active force dipoles
• Active cage model of glassy dynamics
• Nonequilibrium steady state of trapped active particles
• Activity-dependent self-regulation of viscous length scales in biological systems
• Stochastic resetting and first arrival subjected to Gaussian noise and Poisson white noise
• Localization and diffusion of tracer particles in viscoelastic media with active force dipoles
• Nonequilibrium steady states in Langevin thermal systems
• Distribution of active forces in the cell cortex
• Scaling behavior of non-equilibrium measures in internally driven elastic assemblies
• Confined run and tumble particles with non-Markovian tumbling statistics
• Soft inclusion in a confined fluctuating active gel
• Large deviations in statistics of the local time and occupation time for a run and tumble particle
• Mesoscopic non-equilibrium measures can reveal intrinsic features of the active driving
• Information Arbitrage in Bipartite Heat Engines
• Active gels, heavy tails, and the cytoskeleton
• Bona fide stochastic resonance under nonGaussian active fluctuations
• Large deviations in statistics of the convex hull of passive and active particles: A theoretical study
• Dynamical response of a system of passive or active swimmers to time-periodic forcing
• Run-and-tumble particle with saturating rates