The self-assembly and evolution of homomeric protein complexes

Abstract

We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of the protein-protein interactions and (iii) the self-assembly dynamics are hierarchical with these same subcomplexes acting as kinetic intermediates.

4 pages, 4 figures

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• Reversible self-assembly of patchy particles into monodisperse icosahedral clusters
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Cited by in corpus (25)

• The Statistical Mechanics of Dynamic Pathways to Self-assembly
• Self-assembly, modularity and physical complexity
• Monodisperse self-assembly in a model with protein-like interactions
• Self-assembly of monodisperse clusters: Dependence on target geometry
• Extracting bulk properties of self-assembling systems from small simulations
• Beyond icosahedral symmetry in packings of proteins in spherical shells
• Templated self-assembly of patchy particles
• Evolutionary Dynamics in a Simple Model of Self-Assembly
• Designing the self-assembly of arbitrary shapes using minimal complexity building blocks
• Self-assembly of amphiphilic peanut-shaped nanoparticles
• Reentrant phase behaviour for systems with competition between phase separation and self-assembly
• Do hierarchical structures assemble best via hierarchical pathways?
• Approximating the dynamical evolution of systems of strongly-interacting overdamped particles
• Programming patchy particles to form complex periodic structures
• Nonequilibrium growth of patchy-colloid networks on substrates
• Inferring bulk self-assembly properties from simulations of small systems with multiple constituent species and small systems in the grand canonical ensemble
• Hierarchical assembly may be a way to make large information-rich structures
• Design Strategies for Self-Assembly of Discrete Targets
• Nonequilibrium adsorption of 2AnB patchy colloids on substrates
• Assembly of Complex Colloidal Systems Using DNA
• Hierarchical assembly is more robust than egalitarian assembly in synthetic capsids
• Non-deterministic self-assembly of two tile types on a lattice
• The determinism and boundedness of self-assembling structures
• Controlling Fragment Competition on Pathways to Addressable Self-Assembly
• A tractable genotype-phenotype map for the self-assembly of protein quaternary structure