Designing the self-assembly of arbitrary shapes using minimal complexity building blocks

Abstract

The design space for a self-assembled multicomponent objects ranges from a solution in which every building block is unique to one with the minimum number of distinct building blocks that unambiguously define the target structure. Using a novel pipeline, we explore the design spaces for a set of structures of various sizes and complexities. To understand the implications of the different solutions, we analyse their assembly dynamics using patchy particle simulations and study the influence of the number of distinct building blocks and the angular and spatial tolerances on their interactions on the kinetics and yield of the target assembly. We show that the resource-saving solution with minimum number of distinct blocks can often assemble just as well (or faster) than designs where each building block is unique. We further use our methods to design multifarious structures, where building blocks are shared between different target structures. Finally, we use coarse-grained DNA simulations to investigate the realisation of multicomponent shapes using DNA nanostructures as building blocks.

12 pages

References in corpus (14)

• Introducing Improved Structural Properties and Salt Dependence into a Coarse-Grained Model of DNA
• Sequence-dependent thermodynamics of a coarse-grained DNA model
• Reversible self-assembly of patchy particles into monodisperse icosahedral clusters
• Rational design of self-assembly pathways for complex multicomponent structures
• Multifarious Assembly Mixtures: Systems Allowing Retrieval of Diverse Stored Structures
• The self-assembly and evolution of homomeric protein complexes
• Inverse Design for Self Assembly via On-the-Fly Optimization
• The physics of Empty Liquids: from Patchy particles to Water
• Designing patchy interactions to self-assemble arbitrary structures
• Designing the self-assembly of arbitrary shapes using minimal complexity building blocks
• Temperature Protocols to Guide Selective Self-Assembly of Competing Structures
• SAT-assembly: A new approach for designing self-assembling systems
• A simple solution to the problem of self-assembling cubic diamond crystals
• Neuroevolutionary learning of particles and protocols for self-assembly

Cited by in corpus (13)

• Designing the self-assembly of arbitrary shapes using minimal complexity building blocks
• Design strategies for the self-assembly of polyhedral shells
• Escaping kinetic traps using non-reciprocal interactions
• Assembly of Complex Colloidal Systems Using DNA
• Hierarchical assembly is more robust than egalitarian assembly in synthetic capsids
• Automating Blueprints for Colloidal Quasicrystal Assembly
• Accessing Semi-Addressable Self Assembly with Efficient Structure Enumeration
• Designing 3D multicomponent self-assembling systems with signal-passing building blocks
• Inverse design of self-folding 3D shells
• Continuous-time multifarious systems -- Part I: equilibrium multifarious self-assembly
• The polyhedral structure underlying programmable self-assembly
• Continuous-time multifarious systems -- Part II: non-reciprocal multifarious self-organization
• Simultaneous optimization of assembly time and yield in programmable self-assembly