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4 papers · 1 filter
Exceptional error minimization in putative primordial genetic codes
Artem S. Novozhilov, Eugene V. Koonin
We investigated the error-minimization properties of putative primordial codes that consisted of 16 supercodons, with the third base being completely redundant, using a previously…
Mathematical modeling of evolution of horizontally transferred genes
Artem S. Novozhilov, Georgy P. Karev, Eugene V. Koonin
We describe a stochastic birth-and-death model of evolution of horizontally transferred genes in microbial populations. The model is a generalization of the stochastic model descri…
Simple stochastic birth and death models of genome evolution: Was there enough time for us to evolve?
Georgy P. Karev, Yuri I. Wolf, Eugene V. Koonin
We show that simple stochastic models of genome evolution lead to power law asymptotics of protein domain family size distribution. These models, called Birth, Death and Innovation…
Modeling genome evolution with a diffusion approximation of a birth-and-death process
Georgy P. Karev, Faina S. Berezovskaya, Eugene V. Koonin
In our previous studies, we developed discrete-space Birth, Death and Innovation Models (BDIM) of genome evolution. These models explain the origin of the characteristic Pareto dis…