78 citations
- The University of QueenslandAU5 papers
- Indian Institute of Technology RoorkeeIN2 papers
- La Trobe UniversityAU1 paper
- National Imaging FacilityAU1 paper
- National University of SingaporeSG1 paper
- QIMR Berghofer Medical Research InstituteAU1 paper
- University College DublinIE1 paper
- University of AberdeenGB1 paper
7 papers
A globally convergent algorithm for lasso-penalized mixture of linear regression models
Luke R. Lloyd-Jones, Hien D. Nguyen, Geoffrey J. McLachlan
Variable selection is an old and pervasive problem in regression analysis. One solution is to impose a lasso penalty to shrink parameter estimates toward zero and perform continuou…
Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determines the pattern of junctional tension in epithelial cell aggregates
Luke Coburn, Hender Lopez, Adrian Noppe +9
We generated a computational approach to analyze the biomechanics of epithelial cell aggregates, either island or stripes or entire monolayers, that combines both vertex and contac…
Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach
Sriganesh Srihari, Murugan Kalimutho, Samir Lal +5
Copy number alterations (CNAs) are thought to account for 85% of the variation in gene expression observed among breast tumours. The expression of cis-associated genes is impacted…
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer
Sriganesh Srihari, Jitin Singla, Limsoon Wong +1
Background: Synthetic lethality (SL) refers to the genetic interaction between two or more genes where only their co-alteration (e.g. by mutations, amplifications or deletions) res…
Patterns in Space: Coordinating Adhesion and Actomyosin Contractility at E-cadherin Junctions
Selwin K. Wu, Alpha S. Yap
Cadherin adhesion receptors are fundamental determinants of tissue organization in health and disease. Increasingly, we have come to appreciate that classical cadherins exert their…
Evolution and Controllability of Cancer Networks: a Boolean Perspective
Sriganesh Srihari, Venkatesh Raman, Hon Wai Leong +1
Cancer forms a robust system and progresses as stages over time typically with increasing aggressiveness and worsening prognosis. Characterizing these stages and identifying the ge…