113 citations · 409 across the 12 of their papers we have counts for
12 papers
Exploiting synthetic lethal vulnerabilities for cancer therapy
Sriganesh Srihari
Synthetic lethality refers to a combination of two or more genetic events (typically affecting different genes) in which the co-occurrence of the events results in cell or organism…
Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach
Sriganesh Srihari, Murugan Kalimutho, Samir Lal +5
Copy number alterations (CNAs) are thought to account for 85% of the variation in gene expression observed among breast tumours. The expression of cis-associated genes is impacted…
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer
Sriganesh Srihari, Jitin Singla, Limsoon Wong +1
Background: Synthetic lethality (SL) refers to the genetic interaction between two or more genes where only their co-alteration (e.g. by mutations, amplifications or deletions) res…
Challenges and open problems in computational prediction of protein complexes: the case of membrane complexes
Sriganesh Srihari
Identifying the entire set of complexes is essential not only to understand complex formations, but also to map the high level organisation of the cell. Computational prediction of…
Methods for protein complex prediction and their contributions towards understanding the organization, function and dynamics of complexes
Sriganesh Srihari, Chern Han Yong, Ashwini Patil +1
Complexes of physically interacting proteins constitute fundamental functional units responsible for driving biological processes within cells. A faithful reconstruction of the ent…
Parameterized Algorithms for Clustering PPI Networks
Sriganesh Srihari, Hon Wai Leong
With the advent of high-throughput wet lab technologies the amount of protein interaction data available publicly has increased substantially, in turn spurring a plethora of comput…