output
20112025
most citedWeight-conserving characterization of complex functional brain networks

976 citations

21 papers

q-bio.GN2025

Combining multiplexed functional data to improve variant classification

Atlas of Variant Effects Alliance, :, Jeffrey D. Calhoun +10

With the surge in the number of variants of uncertain significance (VUS) reported in ClinVar in recent years, there is an imperative to resolve VUS at scale. Multiplexed assays of…

eess.SP2022★ 15 cited

Ensemble learning using individual neonatal data for seizure detection

Ana Borovac, Steinn Gudmundsson, Gardar Thorvardsson +5

Sharing medical data between institutions is difficult in practice due to data protection laws and official procedures within institutions. Therefore, most existing algorithms are…

eess.SP2020★ 77 cited

Neural Memory Networks for Seizure Type Classification

David Ahmedt-Aristizabal, Tharindu Fernando, Simon Denman +3

Classification of seizure type is a key step in the clinical process for evaluating an individual who presents with seizures. It determines the course of clinical diagnosis and tre…

q-bio.NC2018★ 44 cited

Estimating the impact of structural directionality: How reliable are undirected connectomes?

Penelope Kale, Andrew Zalesky, Leonardo L. Gollo

Directionality is a fundamental feature of network connections. Most structural brain networks are intrinsically directed because of the nature of chemical synapses, which comprise…

q-bio.QM2017

A Fast, Accurate Two-Step Linear Mixed Model for Genetic Analysis Applied to Repeat MRI Measurements

Qifan Yang, Gennady V. Roshchupkin, Wiro J. Niessen +4

Large-scale biobanks are being collected around the world in efforts to better understand human health and risk factors for disease. They often survey hundreds of thousands of indi…

q-bio.NC2017★ 562 cited

Criticality in the brain: A synthesis of neurobiology, models and cognition

Luca Cocchi, Leonardo L. Gollo, Andrew Zalesky +1

Cognitive function requires the coordination of neural activity across many scales, from neurons and circuits to large-scale networks. As such, it is unlikely that an explanatory f…

q-bio.NC2017★ 46 cited

Coexistence of critical sensitivity and subcritical specificity can yield optimal population coding

Leonardo L. Gollo

The vicinity of phase transitions selectively amplifies weak stimuli, yielding optimal sensitivity to distinguish external input. Along with this enhanced sensitivity, enhanced lev…

cs.SI2017★ 26 cited

Validation of a smartphone app to map social networks of proximity

Tjeerd W. Boonstra, Mark E. Larsen, Samuel Townsend +1

Social network analysis is a prominent approach to investigate interpersonal relationships. Most studies use self-report data to quantify the connections between participants and c…

cs.SI2017★ 26 cited

Smartphone app to investigate the relationship between social connectivity and mental health

Tjeerd W. Boonstra, Aliza Werner-Seidler, Bridianne O'Dea +2

Interpersonal relationships are necessary for successful daily functioning and wellbeing. Numerous studies have demonstrated the importance of social connectivity for mental health…

q-bio.QM2016

Quantification of free-living activity patterns using accelerometry in adults with mental illness

Justin J. Chapman, James A. Roberts, Vinh T. Nguyen +1

Physical activity is disrupted in many psychiatric disorders. Advances in everyday technologies (e.g. accelerometers in smart phones) opens exciting possibilities for non-intrusive…

q-bio.NC2016★ 18 cited

Inhibitory loop robustly induces anticipated synchronization in neuronal microcircuits

Fernanda S. Matias, Leonardo L. Gollo, Pedro V. Carelli +2

We investigate the synchronization properties between two excitatory coupled neurons in the presence of an inhibitory loop mediated by an interneuron. Dynamical inhibition together…

q-bio.NC2016★ 166 cited

Mapping how local perturbations influence systems-level brain dynamics

Leonardo L. Gollo, James A. Roberts, Luca Cocchi

The human brain exhibits a relatively stable spatiotemporal organization that supports brain function and can be manipulated via local brain stimulation. Such perturbations to loca…

q-bio.MN2016★ 31 cited

Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach

Sriganesh Srihari, Murugan Kalimutho, Samir Lal +5

Copy number alterations (CNAs) are thought to account for 85% of the variation in gene expression observed among breast tumours. The expression of cis-associated genes is impacted…

q-bio.NC2015★ 25 cited

Diversity improves performance in excitable networks

Leonardo L. Gollo, Mauro Copelli, James A. Roberts

As few real systems comprise indistinguishable units, diversity is a hallmark of nature. Diversity among interacting units shapes properties of collective behavior such as synchron…

q-bio.NC2015★ 182 cited

Dwelling Quietly in the Rich Club: Brain Network Determinants of Slow Cortical Fluctuations

Leonardo L. Gollo, Andrew Zalesky, R. Matthew Hutchison +2

For more than a century, cerebral cartography has been driven by investigations of structural and morphological properties of the brain across spatial scales and the temporal/funct…

q-bio.NC2015

The Organisation of the Elderly Connectome

Alistair Perry, Wei Wen, Anton Lord +3

Investigations of the human connectome have elucidated core features of adult structural networks, particularly the crucial role of hub-regions. However, little is known regarding…

q-bio.NC2014★ 93 cited

The frustrated brain: From dynamics on motifs to communities and networks

Leonardo L. Gollo, Michael Breakspear

Cognitive function depends on an adaptive balance between flexible dynamics and integrative processes in distributed cortical networks. Patterns of zero-lag synchrony likely underp…

q-bio.MN2014

Complex-based analysis of dysregulated cellular processes in cancer

Sriganesh Srihari, Piyush B. Madhamshettiwar, Sarah Song +4

Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined eff…

q-bio.NC2013★ 166 cited

Mechanisms of Zero-Lag Synchronization in Cortical Motifs

Leonardo L. Gollo, Claudio Mirasso, Olaf Sporns +1

Zero-lag synchronization between distant cortical areas has been observed in a diversity of experimental data sets and between many different regions of the brain. Several computat…

q-bio.NC2013★ 36 cited

Single-Neuron Criticality Optimizes Analog Dendritic Computation

Leonardo L. Gollo, Osame Kinouchi, Mauro Copelli

Neurons are thought of as the building blocks of excitable brain tissue. However, at the single neuron level, the neuronal membrane, the dendritic arbor and the axonal projections…

q-bio.NC2011★ 976 cited

Weight-conserving characterization of complex functional brain networks

Mikail Rubinov, Olaf Sporns

Complex functional brain networks are large networks of brain regions and functional brain connections. Statistical characterizations of these networks aim to quantify global and l…