68 citations
4 papers · 1 filter
Measurement of work in single-molecule experiments
Alessandro Mossa, Sara de Lorenzo, Josep Maria Huguet +1
A main goal of single-molecule experiments is to evaluate equilibrium free energy differences by applying fluctuation relations to repeated work measurements along irreversible pro…
Dynamic force spectroscopy of DNA hairpins. II. Irreversibility and dissipation
Maria Manosas, Alessandro Mossa, Nuria Forns +2
We investigate irreversibility and dissipation in single molecules that cooperatively fold/unfold in a two state manner under the action of mechanical force. We apply path thermody…
Dynamic force spectroscopy of DNA hairpins. I. Force kinetics and free energy landscapes
Alessandro Mossa, Maria Manosas, Nuria Forns +2
We investigate the thermodynamics and kinetics of DNA hairpins that fold/unfold under the action of applied mechanical force. We introduce the concept of the molecular free energy…
Bayesian estimates of free energies from nonequilibrium work data in the presence of instrument noise
Paul Maragakis, Felix Ritort, Carlos Bustamante +2
The Jarzynski equality and the fluctuation theorem relate equilibrium free energy differences to non-equilibrium measurements of the work. These relations extend to single-molecule…