most citedSilicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep

103 citations

11 papers

eess.IV2022★ 25 cited

Weakly-supervised detection of AMD-related lesions in color fundus images using explainable deep learning

José Morano, Álvaro S. Hervella, José Rouco +3

Age-related macular degeneration (AMD) is a degenerative disorder affecting the macula, a key area of the retina for visual acuity. Nowadays, it is the most frequent cause of blind…

eess.IV2022

Improving AMD diagnosis by the simultaneous identification of associated retinal lesions

José Morano, Álvaro S. Hervella, José Rouco +3

Age-related Macular Degeneration (AMD) is the predominant cause of blindness in developed countries, specially in elderly people. Moreover, its prevalence is increasing due to the…

q-bio.TO2021★ 30 cited

Response of RAW 264.7 and J774A.1 macrophages to particles and nanoparticles of a mesoporous bioactive glass: A comparative study"

M. J. Feito, L. Casarrubios, M. Onaderra +6

Mesoporous bioactive glasses (MBGs) are bioceramics designed to induce bone tissue regeneration and very useful materials with the ability to act as drug delivery systems. MBGs can…

q-bio.TO2021★ 99 cited

Multifunctional pH sensitive 3D scaffolds for treatment and prevention of bone infection

Cicuendez M, Doadrio JC, Hernandez A +3

Multifunctional-therapeutic 3D scaffolds have been prepared. These biomaterials are able to destroy the S. aureus bacteria biofilm and to allow bone regeneration at the same time.…

q-bio.TO2021★ 8 cited

Effects of mesoporous SiO2-CaO nanospheres on the murine peritoneal macrophages -- Candida albicans interface

R. Diez-Orejas, L. Casarrubios, M. J. Feito +4

The use of nanoparticles for intracellular drug delivery could reduce the toxicity and side effects of the drug but, the uptake of these nanocarriers could induce adverse effects o…

q-bio.TO2021★ 10 cited

Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia

Monica Cicuendez, Joana Flores, Helena Oliveira +4

Nanographene oxide (nGO)-mediated hyperthermia has been increasingly investigated as a localised, minimally invasive anticancer therapeutic approach. Near InfraRed (NIR) light irra…

q-bio.TO2021★ 103 cited

Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep

L. Casarrubios, N. Gomez-Cerezo, S. Sanchez-Salcedo +12

Silicon-substituted hydroxyapatite (SiHA) macroporous scaffolds have been prepared by robocasting. In order to optimize their bone regeneration properties, we have manufactured the…

q-bio.TO2021★ 91 cited

Mesoporous bioactive glass/e-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep

N. Gomez-Cerezo, L. Casarrubios, M. Saiz-Pardo +9

Macroporous scaffolds made of a SiO2-CaO-P2O5 mesoporous bioactive glass (MBG) and epolycaprolactone (PCL) have been prepared by robocasting. These scaffolds showed an excellent in…

q-bio.TO2021★ 30 cited

Incorporation and effects of mesoporous SiO2-CaO nanospheres loaded with ipriflavone on osteoblast/osteoclast cocultures

Laura Casarrubios, Natividad Gomez-Cerezo, Maria Jose Feito +3

Mesoporous nanospheres in the system SiO2-CaO (NanoMBGs) with a hollow core surrounded by a radial arrangement of mesopores were characterized, labeled with FITC (FITC-NanoMBGs) an…

q-bio.TO2021★ 61 cited

Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and macrophages

N. Gomez-Cerezo, L. Casarrubios, I. Morales +4

A mesoporous bioactive glass (MBG) of molar composition 75SiO2-20CaO-5P2O5 (MBG-75S) has been synthetized as a potential bioceramic for bone regeneration purposes. X-ray diffractio…

q-bio.TO2021★ 86 cited

Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment

I. Izquierdo-Barba, L. Santos-Ruiz, J. Becerra +12

The osteogenic and angiogenic responses to metal macroporous scaffolds coated with silicon substituted hydroxyapatite (SiHA) and decorated with vascular endothelial growth factor (…