85 citations
4 papers
VADER: a VAriable Dose-rate External 137Cs irradiatoR for internal emitter and low dose rate studies
Guy Garty, Yanping Xu, Gary W. Johnson +16
Beyond prompt irradiation, Cs-137 is likely to be the most biologically important agent released in many accidental (or malicious) radiation exposure scenarios. Cs-137 either can e…
Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells
I. Tavassoly, J. Parmar, A. N. Shajahan-Haq +3
Autophagy is a conserved biological stress response in mammalian cells that is responsible for clearing damaged proteins and organelles from the cytoplasm and recycling their conte…
A feasible roadmap for unsupervised deconvolution of two-source mixed gene expressions
Niya Wang, Eric P. Hoffman, Robert Clarke +7
Tissue heterogeneity is a major confounding factor in studying individual populations that cannot be resolved directly by global profiling. Experimental solutions to mitigate tissu…
Knowledge-fused differential dependency network models for detecting significant rewiring in biological networks
Ye Tian, Bai Zhang, Eric P. Hoffman +6
Modeling biological networks serves as both a major goal and an effective tool of systems biology in studying mechanisms that orchestrate the activities of gene products in cells.…