85 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- Georgetown UniversityUS15 papers
- University of MichiganUS4 papers
- Harvard UniversityUS3 papers
- Morgridge Institute for ResearchUS3 papers
- Translational Therapeutics (United States)US3 papers
- University of Colorado DenverUS3 papers
- University of PennsylvaniaUS3 papers
- University of Wisconsin–MadisonUS3 papers
- Alex's Lemonade Stand FoundationUS2 papers
- AstraZeneca (United States)US2 papers
- Icahn School of Medicine at Mount SinaiUS2 papers
- Johns Hopkins UniversityUS2 papers
17 papers
Optimal Pair Matching Combined with Machine Learning Predicts a Significant Reduction in Myocardial Infarction Risk in African Americans following Omega-3 Fatty Acid Supplementation
Shudong Sun, Aki Hara, Laurel Johnstone +9
Conflicting clinical trial results on omega-3 highly unsaturated fatty acids (n-3 HUFA) have prompted uncertainty about their cardioprotective effects. While the VITAL trial found…
The Target Polish: A New Approach to Outlier-Resistant Non-Negative Matrix Factorization
Paul Fogel, Christophe Geissler, George Luta
This paper introduces the "Target Polish," a robust and computationally efficient framework for Non-Negative Matrix Factorization (NMF). Although conventional weighted NMF approach…
CoxNTF: A New Approach for Joint Clustering and Prediction in Survival Analysis
Paul Fogel, Christophe Geissler, George Luta
The interpretation of the results of survival analysis often benefits from latent factor representations of baseline covariates. However, existing methods, such as Nonnegative Matr…
Leveraging guidelines for ethical practice of statistics and computing to develop standards for ethical mathematical practice: A White Paper
Catherine Buell, Victor I. Piercey, Rochelle E. Tractenberg
We report the results of our NSF-funded project in which we alpha- and beta- tested a survey comprising all aspects of the ethical practice standards from two disciplines with rele…
A Simple and Practical Approach to Improve Misspellings in OCR Text
Junxia Lin, Johannes Ledolter
The focus of our paper is the identification and correction of non-word errors in OCR text. Such errors may be the result of incorrect insertion, deletion, or substitution of a cha…
Ten Quick Tips for Deep Learning in Biology
Benjamin D. Lee, Anthony Gitter, Casey S. Greene +17
Machine learning is a modern approach to problem-solving and task automation. In particular, machine learning is concerned with the development and applications of algorithms that…
Identification and Development of Therapeutics for COVID-19
Halie M. Rando, Nils Wellhausen, Soumita Ghosh +21
After emerging in China in late 2019, the novel Severe acute respiratory syndrome-like coronavirus 2 (SARS-CoV-2) spread worldwide and as of early 2021, continues to significantly…
Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure
Halie M. Rando, Adam L. MacLean, Alexandra J. Lee +31
The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around the world and infected hundreds of millions of people with coronavirus disease 2019 (COVID-19)…
Optical and magnetic resonance imaging approaches for investigating the tumour microenvironment: state-of-the-art review and future trends
S. Prasad, A. Chandra, M. Cavo +8
The tumour microenvironment (TME) strongly influences tumorigenesis and metastasis. Two of the most characterized properties of the TME are acidosis and hypoxia, both of which are…
BpForms and BcForms: Tools for concretely describing non-canonical polymers and complexes to facilitate comprehensive biochemical networks
Paul F. Lang, Yassmine Chebaro, Xiaoyue Zheng +4
Although non-canonical residues, caps, crosslinks, and nicks play an important role in the function of many DNA, RNA, proteins, and complexes, we do not fully understand how networ…
Geared Rotationally Identical and Invariant Convolutional Neural Network Systems
ShihChung B. Lo, Ph. D., Matthew T. Freedman +4
Theorems and techniques to form different types of transformationally invariant processing and to produce the same output quantitatively based on either transformationally invarian…
Optimizing Trial Designs for Targeted Therapies
Thomas Ondra, Sebastian Jobjörnsson, Robert A. Beckman +4
An important objective in the development of targeted therapies is to identify the populations where the treatment under consideration has positive benefit risk balance. We conside…
Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells
I. Tavassoly, J. Parmar, A. N. Shajahan-Haq +3
Autophagy is a conserved biological stress response in mammalian cells that is responsible for clearing damaged proteins and organelles from the cytoplasm and recycling their conte…
BACOM 2.0 facilitates absolute normalization and quantification of somatic copy number alterations in heterogeneous tumor
Yi Fu, Guoqiang Yu, Douglas A. Levine +5
BACOM is a statistically principled and unsupervised method that detects copy number deletion types (homozygous versus heterozygous), estimates normal cell fraction, and recovers c…
A geometric method for spatiotemporal coherent structure analysis
Chuan Zhang, Kentaroh Takagaki, Xiaoying Huang +2
We describe a geometric method to quantify wave patterns observed in the nervous system, which are non-stationary and with a mixture of spiral, target, plane and irregular waves. T…
Synaptic potentiation facilitates memory-like attractor dynamics in cultured in vitro hippocampal networks
Mark Niedringhaus, Xin Chen, Katherine Conant +1
Collective rhythmic dynamics from neurons is vital for cognitive functions such as memory formation but how neurons self-organize to produce such activity is not well understood. A…
Observed network dynamics from altering the balance between excitatory and inhibitory neurons in cultured networks
Xin Chen, Rhonda Dzakpasu
Complexity in the temporal organization of neural systems may be a reflection of the diversity of its neural constituents. These constituents, excitatory and inhibitory neurons, co…