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- Centre National de la Recherche ScientifiqueFR6 papers
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5 papers · 1 filter
Kinetic Model for a Threshold Filter in an Enzymatic System for Bioanalytical and Biocomputing Applications
Vladimir Privman, Sergii Domanskyi, Shay Mailloux +2
A recently experimentally observed biochemical "threshold filtering" mechanism by processes catalyzed by the enzyme malate dehydrogenase is explained in terms of a model that incor…
Can bio-inspired information processing steps be realized as synthetic biochemical processes?
Vladimir Privman, Evgeny Katz
We consider possible designs and experimental realiza-tions in synthesized rather than naturally occurring bio-chemical systems of a selection of basic bio-inspired information pro…
Realization of Associative Memory in an Enzymatic Process: Towards Biomolecular Networks with Learning and Unlearning Functionalities
Vera Bocharova, Kevin MacVittie, Soujanya Chinnapareddy +3
We report a realization of an associative memory signal/information processing system based on simple enzyme-catalyzed biochemical reactions. Optically detected chemical output is…
Enzyme-Based Logic Analysis of Biomarkers at Physiological Concentrations: AND Gate with Double-Sigmoid "Filter" Response
Jan Halamek, Oleksandr Zavalov, Lenka Halamkova +3
We report the first realization of a biomolecular AND gate function with double-sigmoid response (sigmoid in both inputs). Two enzyme biomarker inputs activate the gate output sign…
Spontaneous Reaction Silencing in Metabolic Optimization
Takashi Nishikawa, Natali Gulbahce, Adilson E. Motter
Metabolic reactions of single-cell organisms are routinely observed to become dispensable or even incapable of carrying activity under certain circumstances. Yet, the mechanisms as…